Registration Dossier
Registration Dossier
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EC number: 210-441-2 | CAS number: 615-66-7
Endpoint summary
Administrative data
Description of key information
Stability
Hydrolysis
The hydrolysis study of 2-chloro-p-phenylenediamine was predicted using OECD QSAR toolbox version 3.3 (2017) to predict the hydrolysis half-life of test compound 2-chloro-p-phenylenediamine (CAS No.615-66-7).The half-life of 2-chloro-p-phenylenediamine was estimated to be 167.64 days at temperature 25 degC, indicating that the substance 2-chloro-p-phenylenediamine is not hydrolysable.
Additional information
Stability
Hydrolysis
In a different studies, 2-chloro-p-phenylenediamine (CAS No.615-66-7) has been investigated for its hydrolysis potential to a greater or lesser extent. These include predicted and experimental study for target substance 2-chloro-p-phenylenediamine (CAS No.615-66-7) and for its closest read across substances 3-Chloroaniline (CAS No.- 108-42-9), 2,4,6-trichloroaniline (CAS No.- 634-93-5) and 3,4-Dichloroaniline (CAS No.- 95-76-1) by considering its structure-activity relationships, were reviewed and are summarized as follows:
The hydrolysis study of 2-chloro-p-phenylenediamine was predicted using OECD QSAR toolbox version 3.3 (2017) to predict the hydrolysis half-life of test compound 2-chloro-p-phenylenediamine (CAS No.615-66-7).The half-life of 2-chloro-p-phenylenediamine was estimated to be 167.64 days at temperature 25 degC, indicating that the substance 2-chloro-p-phenylenediamine is not hydrolysable.
Supported by the study from an authoritative database (Hazardous Substances Data Bank (HSDB, 2017) for a read across substance 3-Chloroaniline (CAS No.- 108-42-9).The substance 3-Chloroaniline (CAS No.- 108-42-9) is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups.
In addition, the study from the same authoritative database (Hazardous Substances Data Bank (HSDB, 2017) indicates that the substance 2,4,6-trichloroaniline (CAS No.- 634-93-5) is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups.
Moreover, the substance 3,4-Dichloroaniline (CAS No.- 95-76-1) is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups . (HSDB, 2017)
Based on the above available studies for the target and read across substance, it can be concluded that the test substance 2-chloro-p-phenylenediamine (CAS No.615-66-7) is not expected to undergo hydrolysis in the environment i.e., it is not hydrolysable.
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