Registration Dossier
Registration Dossier
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EC number: 210-441-2 | CAS number: 615-66-7
Endpoint summary
Administrative data
Description of key information
Bioaccumulation
Bioaccumulation: aquatic / sediment
The BCFBAF program v3.01 of Estimation Programs Interface (EPI) Suite (2017) prediction model was used to predict the bioconcentration factor of 2-chloro-p- phenylenediamine (CAS No. 615-66-7). The bioconcentration factor (BCF) for 2-chloro-p-phenylenediamine is estimated as 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000 as per Annex XIII of REACH regulation. Thus, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615-66-7) does not qualify as bio-accumulative substance. This BCF also suggests the potential for bioconcentration in aquatic organisms is low.
Additional information
Bioaccumulation
Bioaccumulation: aquatic / sediment
The substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) has been investigated for its environ mental bioconcentration potential (BCF) to a greater or lesser extent. These include various predicted result from validated model for target chemical 2-chloro-p-phenylenediamine (CAS No. 615-66-7)and experimental data for its read across substances 3-chloroaniline (CAS No.- 108-42-9) and 3,4-dichlo roaniline (CAS No.- 95-76-1) by considering its structure-activity relationships. The studies are summarized as follows:
The BCFBAF program v3.01 of Estimation Programs Interface (EPI) Suite (2017) prediction model was used to predict the bioconcentration factor of 2-chloro-p-phenylenediamine (CAS No. 615-66-7). The bioconcentration factor (BCF) for 2-chloro-p-phenylenediamine is estimated as 3.162 L/kg wet-wt.
In a study conducted byT. Tsuda et al. (Chemosphere 1993, 26(12), 2301-2306.), the bioconcent ration factor (24-336 hr exposure) for carp exposed to 14.7 and 0.67 µg/L under continuous flow-through conditions, 0.8 and 2.2, respectively. Whole-body excretion rate constant 0.21 hr-1. This low value of BCF indicates that 3-chloroaniline does not qualify as bio-accumulative substance as the BCF factor is less than the bio-concentration threshold of 2000 as per Annex XIII of REACH regulation. This BCF also suggests the potential for bioconcentration in aquatic organisms is low.
Moreover, based on the study from an authoritative database [HSDB(Hazardous Substances Data Bank) (2017)], a BCF of 30.2 was determined for 3,4-dichloroaniline under static conditions with 60 male zebra fish for 10 hours. According to a classification scheme, this BCF suggests the potential for bioconcen tration in aquatic organisms is low.
Based on the above predicted studies for target substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) and to its read across substances 3-chloroaniline (CAS No.- 108-42-9) and 3,4-dichloroaniline (CAS No.- 95-76-1), the bioconcentration factor (BCF) was found to be in the range of 0.8 – 30.2 (dimension less or L/kg wet-wt) at temperature 25 degC. These BCF values does not exceed the bioconcentration threshold of 2000 as per Annex XIII of REACH regulation. Thus, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615-66-7) does not qualify as bio-accumulative substance. This BCF also suggests the potential for bioconcentration in aquatic organisms is low.
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