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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source.

Data source

Reference
Reference Type:
secondary source
Title:
OPINION ON 2-Chloro-p-phenylenediamine COLIPA n° A8
Author:
European Cosmetics Toiletry and Perfumery Association (COLIPA)
Year:
2013
Bibliographic source:
Scientific Committee on Consumer Safety (SCCS), SCCS/1510/13, 19 September 2013

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The study was conducted to evaluate the acute toxic effects of administration of 2-chloro-p-pheynelenediamine (CAS No. 615-66-7) in rats by the oral route.
GLP compliance:
not specified
Test type:
other: No data available

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloro-p-phenylenediamine
EC Number:
210-441-2
EC Name:
2-chloro-p-phenylenediamine
Cas Number:
615-66-7
Molecular formula:
C6H7ClN2
IUPAC Name:
2-chlorobenzene-1,4-diamine
Details on test material:
- Name of test material (as cited in study report): 2-Chloro-p-phenylenediamine
- Molecular formula (if other than submission substance): C6H7N2Cl
- Molecular weight (if other than submission substance): 142.588 g/mole
- Substance type: Organic
- Physical state: Solid
- Purity 99%
- Impurities (identity and concentrations): 1 %

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
729 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
other: Category 4 based on CLP criteria
Conclusions:
The acute oral median lethal dose (LD50) of 2-chloro-p-phenylenediamine in rat was observed to be 729 mg/kg bw.
Executive summary:

The study was conducted to evaluate the acute toxic effects of administration of 2-chloro-p-pheynelenediamine (CAS No. 615-66-7) in rats by the oral route. The acute oral median lethal dose (LD50) of 2-chloro-p-phenylenediamine in rat was observed to be 729 mg/kg bw. Thus, according to CLP criteria for acute toxicity rating for the chemicals, it infers that 2-chloro-p-phenyl enediamine (CAS No. 615-66-7) can be classify under category 4 compound at the tested dose levels.

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