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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer -reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: 2-nonanone
Author:
Moreno, O. M.
Year:
1988
Bibliographic source:
Food and Chemical Toxicology Volume 26, Issue 4, 1988, Pages 393

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: No data
Principles of method if other than guideline:
Acute dermal toxicity study of nonan-2-one in rabbits
GLP compliance:
no
Test type:
other: No data
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Nonan-2-one
EC Number:
212-480-0
EC Name:
Nonan-2-one
Cas Number:
821-55-6
Molecular formula:
C9H18O
IUPAC Name:
nonan-2-one
Constituent 2
Reference substance name:
2-Nonanone
IUPAC Name:
2-Nonanone
Details on test material:
- Name of test material (as cited in study report): 2-nonanone
- Molecular formula (if other than submission substance): C9H18O
- Molecular weight (if other than submission substance): 142.24g/mol
- Substance type: Organic
- Physical state: colorless to pale yellow clear oily liquid
Purity No data available
Specific details on test material used for the study:
- Name of test material: 2-Nonanone (nonan-2-one )
- IUPAC name: nonan-2 -one
- Molecular formula: C9H18O
- Molecular weight: 142.24g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data available
- Impurities (identity and concentrations): No data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
24 hour
Doses:
5000 mg/kg
No. of animals per sex per dose:
7
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: no data
- Frequency of observations and weighing:no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: mortality, clinical signs and gross pathology were observed.
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed in all seven animals.
Mortality:
No mortality was observed in all seven animals.
Clinical signs:
Irritation was observed in treated rabbits at 5000 mg/kg bw
Body weight:
No data available
Gross pathology:
scaly skin was observed in treated rabbits at 5000 mg/kg bw
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered t be > 5000 mg/kg bw when rabbits were treated with nonan-2-one by dermal application.
Executive summary:

In a acute oral toxicity study, 7 rabbits were treated with nonan-2-one in the concentration of 5000 mg/kg bw orally. No mortality were observed in treated rabbits at 5000 mg/kg bw. Irritation and scaly skin was observed in treated rabbits at 5000 mg/kg bw. Therefore, LD50 was considered t be > 5000 mg/kg bw when rabbits were treated with nonan-2-one by dermal application.

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