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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: 2-Nonanone
Author:
Edited by D.L.J Opdyke
Year:
1988
Bibliographic source:
Food and Chemical Toxicology Volume 26, Issue 4, 1988, Pages 393

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation test was performed for Methyl heptyl ketone in rabbit over a period of 24 hour by patch test method.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Nonan-2-one
EC Number:
212-480-0
EC Name:
Nonan-2-one
Cas Number:
821-55-6
Molecular formula:
C9H18O
IUPAC Name:
nonan-2-one
Constituent 2
Reference substance name:
Methyl heptyl ketone
IUPAC Name:
Methyl heptyl ketone
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 2-nonanone
- Molecular formula: C9H18O
- Molecular weight: 142.24g/mol
- Smiles notation: C(CCCCC)CC(C)=O
- InChI: 1S/C9H18O/c13456789(2)10/h38H2,12H3
- Substance type: Organic
- Physical state: colorless to pale yellow clear oily liquid

Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-nonanone
- Molecular formula: C9H18O
- Molecular weight: 142.24g/mol
- Smiles notation: C(CCCCC)CC(C)=O
- InChI: 1S/C9H18O/c13456789(2)10/h38H2,12H3
- Substance type: Organic
- Physical state: colorless to pale yellow clear oily liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
other: Undiluted material was applied on the skin.
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
>5000 mg/kg
Duration of treatment / exposure:
24 hour
Observation period:
24 hour
Number of animals:
no data available
Details on study design:
No data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritant / corrosive response data:
Irritation effects and scaly skin was observed at necropsy in the test animals.
Based on the observations, 2-nonanone can be considered as a skin irritant.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Irritation effects and scaly skin was observed at necropsy in rabbits.
Based on the observations, 2-nonanone can be considered as a skin irritant.
Executive summary:

A skin irritation study was performed as a part of Acute dermal toxicity study in rabbits to evaluate the irritation potential of 2-nonanone.

5.0g/kg of undiluted 2-nonanone was applied under occlusion patch test to rabbits for 24 hours. Irritation effects and scaly skin was observed at necropsy in rabbits.

Based on the observations, 2-nonanone can be considered as a skin irritant.