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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from peer review journals

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicity of a Homologous Series of Branched-Chain Primary Alcohols
Author:
R. A. SCALA & E. G. BURTIS
Year:
1973
Bibliographic source:
American Industrial Hygiene Association Journal, (1973), 34:11, 493-499

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
In vivo study performed on albino Rabbit.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Tridecan-1-ol
EC Number:
203-998-8
EC Name:
Tridecan-1-ol
Cas Number:
112-70-9
IUPAC Name:
tridecan-1-ol
Test material form:
solid
Details on test material:
- Name of test material: tridecan-1-ol
- Molecular formula: C13H28 O
- Molecular weight: 200.37 g/mole
- Substance type: Solid
- Physical state: Organic
Specific details on test material used for the study:
- Name of test material: tridecan-1-ol
- Molecular formula: C13H28 O
- Molecular weight: 200.37 g/mole
- Substance type: Solid
- Physical state: Organic

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
not specified
Controls:
yes
Amount / concentration applied:
0.1 ml of undiluted alcohol
Duration of treatment / exposure:
Treated eye was closed for 30 seconds
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
Six
Details on study design:
TEST SITE
Area of exposure: conjuctival sac of left eye
% coverage: No data
Type of wrap if used: no wrap used

REMOVAL OF TEST SUBSTANCE
Washing (if done): no washing performed
Time after start of exposure: not applicable

SCORING SYSTEM: Grading scale is slight-moderate-marked and severe.
Signs of irritation exposure were graded and scored according to the method of Draize.

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
4
Reversibility:
fully reversible within: 7 days
Remarks on result:
probability of moderate irritation
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
72 h
Score:
0
Reversibility:
fully reversible within: 7 days
Remarks on result:
no indication of irritation
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Score:
0
Reversibility:
fully reversible within: 7 days
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Tridecyl alcohol caused little irritation in most of the animals, but persistent corneal opacity

Any other information on results incl. tables

Score:

Alcohol

Irritation

Median Score

24 hr

72 hr

7 days

Tridecyl alcohol

Moderate

4

0

0

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Acute toxicity studies were carried out to evaluate the toxicity of tridecyl alcohol
Tridecyl alcohol caused little eye irritation in most of the animals, but persistent corneal opacity in one caused the classification as moderate.
Tridecyl alcohol can be considered as moderately irritating to eyes.
Executive summary:

Acute toxicity studies were carried out to evaluate the toxicity of tridecyl alcohol.

A single application of 0.1 ml of undiluted tridecyl alcohol was made into the conjunctival sac of the left eye of each of six rabbits. The untreated eye served as the control. The treated eye was closed for 30 seconds and eyes were not washed. Observations for irritancy and possible systemic toxicity were made at 1, 4, and 24 hours and at 2, 3, 4, and 7 days. Where positive effects persisted, observations were continued initially and at termination the eyes were examined following instillation of 2 % sodium fluorescein solution to detect any corneal lesions if not otherwise visible. Grading scale is slight-moderate-marked and severe.Signs of irritation exposure were graded and scored according to the method of Draize.

Tridecyl alcohol caused little irritation in most of the animals, but persistent corneal opacity in one caused the classification as moderate.

Tridecyl alcohol can be considered as moderately irritating to eyes.

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