Tridecan-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal.

Data source

Reference

Reference Type:

publication

Title:

Acute Toxicity to the rat

Author:

SCALA et al.

Year:

1973

Bibliographic source:

American Industrial Hygiene Association Journal

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as per mentioned below

Principles of method if other than guideline:

Acute oral toxicity of the given test chemical in rat.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tridecan-1-ol

EC Number:

203-998-8

EC Name:

Tridecan-1-ol

Cas Number:

112-70-9

Molecular formula:

C13H28O

IUPAC Name:

tridecan-1-ol

Test material form:

solid: crystalline

Details on test material:

- Name of test material (as cited in study report): tridecan-1-ol
- Molecular formula : C13H28O
- Molecular weight : 200.37 g/mol
- Smiles notation (if other than submission substance): C(CCCCCCO)CCCCCC
- InChl (if other than submission substance): 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Substance type: Organic
- Physical state: Solid

Specific details on test material used for the study:

- Name of test material (as cited in study report): tridecan-1-ol
- Molecular formula : C13H28O
- Molecular weight : 200.37 g/mol
- Smiles notation (if other than submission substance): C(CCCCCCO)CCCCCC
- InChl (if other than submission substance): 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Substance type: Organic
- Physical state: Solid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

Fasting period before study: 3-4 hours prior to study
Housing: Group - housed
Diet (e.g. ad libitum):ad libitum
Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

Concentration in vehicle: 0.032 to 10.0 ml/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10.0 ml/kg bw
CLASS METHOD (if applicable):
Rationale for the selection of the starting dose: A dosing schedule employing half log separations and ranging from 0.032 to 10.0 ml/kg body weight was generally used. The results have been converted to weight units by means of the specific gravity.

Doses:

4750 mg/kg bw

No. of animals per sex per dose:

groups of 5 male rats

Control animals:

not specified

Details on study design:

Duration of observation period following administration: 14 days (or other?): 7 to 14 days
Frequency of observations and weighing: Observations for signs of toxicity were made frequently on the day of administration and daily thereafter for a period of 7 to 14 days
Necropsy of survivors performed: yes/no: Yes

Statistics:

The mortality data were analyzed by the moving average of Horn or the method of Litchfield and Wilcoxon. The results have been converted to weight units by means of the specific gravity.

Results and discussion

Preliminary study:

No data

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

4 750 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% Mortality observed at 4750 mg/kg bw

Mortality:

50% Mortality observed at 4750 mg/kg bw.

Clinical signs:

other: The principal signs of effect were central nervous system depression and labored respiration. The depression included inactivity, ataxia, limb sprawling, depressed righting and placement reflexes, prostration, and coma.

Gross pathology:

Gross necropsy revealed some evidence of gastrointestinal irritation.

Other findings:

No data

Any other information on results incl. tables

Table: Acute Oral toxicity of Alcohols

Alcohol	Carbon No.	LD50 gm/kg
Tridecyl	13	4.75^a

 

a- LD50 value was estimated, since mortality pattern was not suitable for analysis.

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

Based on all the available data, it was concluded that acute oral toxicity dose (LD50) was considered to be 4750 mg/kg bw, when groups of 5 male Sprague-Dawley rats were treated with the given test chemical via oral gavage route.

Executive summary:

An acute oral toxicity study was conducted by using test chemical in groups of 5 male Sprague-Dawley rats at the concentration ranging from 0.032 to 10.0 ml/kg body weight. The given test chemical was dissolved in a corn oil suspension or in undiluted form. The animals had been fasted for 3 to 4 hours prior to the study and were group-housed, with water and feed freely available after dosing. Observations for signs of toxicity were made frequently on the day of administration and daily thereafter for a period of 7 to 14 days. Gross necropsy examinations were performed on all animals that died or were killed. The mortality data were analyzed by the moving average of Horn or the method of Litchfield and Wilcoxon. The results have been converted to weight units by means of the specific gravity. LD50 was estimated, since mortality pattern was not suitable for analysis. 50% Mortality observed at 4750 mg/kg bw.The principal signs of effect were central nervous system depression and labored respiration. The depression included inactivity, ataxia, limb sprawling, depressed righting and placement reflexes, prostration, and coma. Gross necropsy revealed some evidence of gastrointestinal irritation. Therefore, the acute oral toxicity dose (LD50) was considered to be 4750 mg/kg bw, when groups of 5 male Sprague-Dawley rats were treated with the test chemical via oral gavage route.