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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from IFA GESTIS authoritive database

Data source

Reference
Reference Type:
other: authoritive database
Title:
Eye irritation test for 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn).

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
An ocular irritation study of 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1) was conducted on rabbits to determine its potential of causing eye irritation according to OECD 405.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-2,5-dimethoxyaniline
EC Number:
228-782-0
EC Name:
4-chloro-2,5-dimethoxyaniline
Cas Number:
6358-64-1
Molecular formula:
C8H10ClNO2
IUPAC Name:
4-chloro-2,5-dimethoxyaniline
Details on test material:
- IUPAC Name: 4-chloro-2,5-dimethoxyaniline
- Mol. formula: C8H10ClNO2
- Molecular Weight: 187.625 g/mole
- Smiles: c1(c(cc(OC)c(c1)Cl)N)OC
- InChI: 1S/C8H10ClNO2/c1-11-7-4-6(10)8(12-2)3-5(7)9/h3-4H,10H2,1-2H3
Specific details on test material used for the study:
- IUPAC Name: 4-chloro-2,5-dimethoxyaniline
- Mol. formula: C8H10ClNO2
- Molecular Weight: 187.625 g/mole
- Smiles: c1(c(cc(OC)c(c1)Cl)N)OC
- InChI: 1S/C8H10ClNO2/c1-11-7-4-6(10)8(12-2)3-5(7)9/h3-4H,10H2,1-2H3

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
72 hours
Observation period (in vivo):
72 hours
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
72 h
Reversibility:
fully reversible within: 72 h
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
The chemical produced only minor irritations that subsided within 72 hours.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)was considered to be not irritating to the rabbits’ eye.
Executive summary:

An ocular irritation study of 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1) was conducted on rabbits to determine its potential of causing eye irritation according to OECD 405.

 

The chemical triggered only minor irritations that subsided within 72 hours when installed into the eyes of each rabbits.

 

Therefore under the test condition, the chemical 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)was considered to be not irritating to the rabbits’ eye.