Registration Dossier
Registration Dossier
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EC number: 201-923-3 | CAS number: 89-61-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- other: secondary source
- Title:
- Initial Submission: The Toxicity of p-Chlor-o-Nitraniline, o-Chlor-p-Nitraniline, 2, 5-Dichloronitrobenzene, And 3, 4-Dichlornitrobenzene (Final Report) With Letter 031892 (Sanitized)
- Author:
- Dow Chemical Company - NTRL
- Year:
- 1 992
- Bibliographic source:
- Dow Chemical Company Report 24 March 1992 - NTRL report
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- 2, 5-Dichloronitrobenzene was evaluated for its toxic nature upon its acute oral administration in Guinea pigs.
- GLP compliance:
- not specified
- Test type:
- other: No data available
Test material
- Reference substance name:
- 1,4-dichloro-2-nitrobenzene
- EC Number:
- 201-923-3
- EC Name:
- 1,4-dichloro-2-nitrobenzene
- Cas Number:
- 89-61-2
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,4-dichloro-2-nitrobenzene
- Reference substance name:
- 1,4-dichloro-2- nitrobenzene
- IUPAC Name:
- 1,4-dichloro-2- nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2, 5-Dichloronitrobenzene
- Molecular formula (if other than submission substance): C6-H3-Cl2-N-O2
- Molecular weight (if other than submission substance): 192.001 g/mol
- Substance type: Organic
- Physical state: Solid
- Purity: No data available
Constituent 1
Constituent 2
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 5% gum acacia solution
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1200, 1000, 800, 600 and 500 mg/Kg
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: No data available
- Lot/batch no. (if required): No data available
- Purity: No data available
MAXIMUM DOSE VOLUME APPLIED: No data available
DOSAGE PREPARATION (if unusual): No data available
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data available - Doses:
- 1200, 1000, 800, 600 and 500 mg/Kg
- No. of animals per sex per dose:
- 14
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 800 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- 2, 5 dichloronitrobenzene was fairly toxic and likewise produced some irritation in the kidneys.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 for the test material 2, 5 dichloronitrobenzene is found to be 800mg/Kg.
- Executive summary:
2, 5-Dichloronitrobenzene was evaluated for its toxic nature upon its acute oral administration in Guinea pigs.
The test compoundwas fairly toxic and likewise produced some irritation in the kidneys.
The acute oral LD50 for the test material2, 5 dichloronitrobenzene is found to be 800mg/Kg.
According to the publication, the test material classifies as an acute toxicant Category 4 chemical.
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