Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-Hydroxy-2-[(2E)-2-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)ethyl]-2-methylcyclopentanone
EC Number:
613-827-2
Cas Number:
6563-82-2
Molecular formula:
C19H24O3
IUPAC Name:
3-Hydroxy-2-[(2E)-2-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)ethyl]-2-methylcyclopentanone

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
3.16 mg/L
Nominal / measured:
estimated
Remarks on result:
other: (Q)SAR Toolbox, Database: Aquatic OASIS (Fathead minnow)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
3.78 mg/L
Nominal / measured:
estimated
Remarks on result:
other: (Q)SAR Toolbox, Database: Aquatic OASIS (Fathead minnow)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
3.37 mg/L
Nominal / measured:
estimated
Remarks on result:
other: T.E.S.T. (SMM)

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: QSAR Toolbox and T.E.S.T., the predicted values indicated that methyl-secoolon is hazardous to the fish. The result meets the requirement of Aquatic Acute Category 2.