Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-763-0 | CAS number: 72676-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.11: PBT/vPvB assessment (Version 3.0 June 2017) a PBT assessment must take into account the PBT/vPvB properties of relevant constituents and relevant transformation and/or degradation products. Although 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione undergoes non-hydrolytic transformation when exposed to a protic solvent, the transformation is more accurately described as tautomerization. Tautomers are considered to be the same compound of the parent substance; therefore, PBT Assessments of each tautomer would not be appropriate.
Persistence (P)
In an OECD Guideline 301B study, conducted according to GLP, 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione achieved 0% biodegradation after 28 days and is therefore considered as not readily biodegradable (Harlan Laboratories, Ltd, 2016).
According to Table R.11-4 of ECHA’s guidance on information requirements and chemical safety assessment chapter R11 (v3.0, June 2017, p.49), 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione should be considered as potentially P or vP.
Bioaccumulation (B)
In a study conducted according to GLP, the partition coefficient (log Pow) of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione estimated based on the ratio of n-octanol solubility and water solubility is 1.46 at 25 ± 1°C (Intertek Pharmaceutical Services Manchester, 2016).
According to Figure R.11-4 of ECHA’s guidance on information requirements and chemical safety assessment chapter R11 (v3.0, June 2017, p.68), 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione should be considered as not B and not vB.
Toxic (T)
As the substance does not meet the B/vB criteria, no assessment is needed on the T criterion and the substance is not considered PBT or vPvB,
Overall Summary:
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.11: PBT/vPvB assessment (Version 3.0 June 2017) 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione should not be considered as PBT or vPvB.
- Likely routes of exposure:
Based upon the hazard profile, 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is classified as Aquatic Chronic Category 2, Toxic to aquatic life with long lasting effects
.
During normal industrial activities no release directly to the environment is expected. The generation of waste should be avoided or minimized wherever possible.
The following environmental RMM must be followed:
Do not intentionally release the substance or products containing the substance directly to the environment;
Prevent discharge of un-dissolved substance to or recover from onsite wastewater;
Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers;
Use appropriate storage containment to avoid environmental contamination;
The generation of waste should be avoided or minimized wherever possible.
Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements;
Waste should be recycled wherever possible;
Incineration of waste or landfill should only be considered when recycling is not feasible;
Dispose of surplus and non-recyclable products must be via a licensed waste disposal contractor;
Waste packaging should be recycled;
Care should be taken when handling emptied containers that have not been cleaned or rinsed out;
Emissions from ventilation or work process equipment should comply with the requirements of local environmental protection legislation;
Fume scrubbers, filters or engineering modifications to the process equipment should be considered to minimalise emissions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1