A mixture of: propan-2-one-O,O'-(methoxymethylsilandiyl)dioxime; propan-2-one-O-(dimethoxymethylsilyl)oxime; propan-2-one-O,O',O''-(methylsilantriyl)trioxime

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Data waiving:

study technically not feasible

Justification for data waiving:

other:

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
Due to the nature of the test material, it was not possible to determine the vapour pressure of the test material using the vapour pressure balance or isoteniscope methods.

Reason / purpose for cross-reference:

data waiving: supporting information

Reference 2

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

According to OECD Guideline 104, with GLP.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Principles of method if other than guideline:

Attempts were made to determine the vapour pressure using both, Vapour Pressure Balance and Isoteniscope System.

GLP compliance:

yes

Type of method:

other: Isoteniscope and Vapour Balance Methods

Attempts were made to determine the vapour pressure using both a vapour pressure balance and an isoteniscope system:

A) Vapour Pressure Balance Procedure:

Balance readings were taken at 15 and 5°C. At both temperatures the readings were high (2121.18 and 1689.25 jlg) and in each case the instrument could not maintain the vacuum required to operate.

B) Isoteniscope Procedure: The sample decomposed prior to obtaining suitable manometer readings. The sample had been heated to 217.8°C and had turned to a black liquid.

It was not possible to determine the vapour pressure of the test material using the vapour pressure balance or isoteniscope methods.

Conclusions:

It was not possible to determine the vapour pressure using neither the vapour pressure balance nor isoteniscope method.

Executive summary:

A determination of vapour pressure on test item Wasox-MMAC2 was performed according to EU Method A.4. Attempts were using both a vapour pressure balance and an isoteniscope system. Balance readings were taken at 15 and 5°C. At both temperatures the readings were high (2121.18 and 1689.25 jlg) and in each case the instrument could not maintain the vacuum required to operate. In the isoteniscope procedure, the sample decomposed prior to obtaining suitable manometer readings. The sample had been heated to 217.8°C and had turned to a black liquid.

Therefore and due to the nature of the test material, it was not possible to determine the vapour pressure of the test material using the vapour pressure balance or isoteniscope methods.

Reference 3

Endpoint:

vapour pressure

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Remarks:

Internationally accepted method, EPI Suite, EPA (USA)

Justification for type of information:

See attached QSAR supporting information

Principles of method if other than guideline:

Calculation by atom/fragment contribution method using the software MPBPWIN Version v. 1.41 2000, of the U.S. Environmental Protection Agency

Specific details on test material used for the study:

SMILES of components:
MMAC2: CC( C)=N O[Si] (C)( OC )ON=C( C )C
MAC3: CC( C)=NO[Si] (C)( 0 N=C( C)C)O N=C( C )C
MM2AC: CC(C)=NO[Si](C)(OC)OC.

Temp.:

25 °C

Vapour pressure:

8.87 Pa

Remarks on result:

other: Propan-2-one-O,O'-(methoxymethylsilandiyl) dioxime

Temp.:

25 °C

Vapour pressure:

0.523 Pa

Remarks on result:

other: Propan-2-one-O,O',O''-(methylsilantriyl)trioxime

Temp.:

25 °C

Vapour pressure:

205 Pa

Remarks on result:

other: Propan-2-one-O-(dimethoxymethylsilyl)oxime

Conclusions:

The calculated vapour pressures of the three main components of the test substance Wasox-MMAC2 were: 205 Pa at 25 ºC for Propan-2-one-O-(dimethoxymethylsilyl)oxime; 8.87 Pa at 25 ºC for Propan-2-one-O,O'-(methoxymethylsilandiyl) dioxime and 0.523 Pa at 25 ºC for Propan-2-one-O,O',O''-(methylsilantriyl)trioxime.

Executive summary:

Using the software MPBPWIN Version v1.4 2000, of the U.S. Environmental Protection Agency the calculated vapour pressure of the three main components of the test substance Wasox-MMAC2 were: 205 Pa at 25 ºC for Propan-2-one-O-(dimethoxymethylsilyl)oxime; 8.87 Pa at 25 ºC for Propan-2-one-O,O'-(methoxymethylsilandiyl) dioxime and 0.523 Pa at 25 ºC for Propan-2-one-O,O',O''-(methylsilantriyl)trioxime.

Description of key information

Data waiving (study technically not feasible): EU Methd A.4 and GLP. It was not possible to determine the vapour pressure using neither the vapour pressure balance nor isoteniscope method.

Additional information

Data waiving (study technically not feasible): A determination of vapour pressure on Wasox-MMAC2 was performed according to EU Method A.4 and GLP. Due to the nature of the test material, it was not possible to determine the vapour pressure of the test material using the vapour pressure balance or isoteniscope methods.

Supporting study: Using the software MPBPWIN Version v1.4 2000, of the U.S. Environmental Protection Agency the calculated vapour pressure of the three main components of the test substance Wasox-MMAC2 were: 205 Pa at 25 ºC for Propan-2-one-O-(dimethoxymethylsilyl)oxime; 8.87 Pa at 25 ºC for Propan-2-one-O,O'-(methoxymethylsilandiyl) dioxime and 0.523 Pa at 25 ºC for Propan-2-one-O,O',O''-(methylsilantriyl)trioxime.