Registration Dossier
Registration Dossier
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EC number: 213-888-1 | CAS number: 1052-38-6
Endpoint summary
Administrative data
Description of key information
Additional information
Acute tests on two trophic levels are available on Solvent brown 41, i.e. the acute fish and aquatic (Dafnia) invertebrates toxicity.
The studies showed precipitation under the experimental conditions, setting the limit of testing at the solubility limits.
In particular, two studies performed on Zebra fishes for Solvent Brown 41 showed precipitation of the substance in the medium, setting the LC0, 96h at ca. 0.74 mg/l.
Another study, performed on Dafnia, for Solvent brown 41 showed, after precipitation, an EC50 (EC0), 48h = 1.24 mg/l (measured concentration, solubility limit under the test conditions).
Morover, due to the insolubility of the substance in water, a test for assessing acute toxicity on aquatic plants, in particular algae, has been considered not applicable and representative. In fact, based on the REACH Regulation, Annex VII, Column 2 (specific rules for adaptation from column 1) the algae study does not need to be conducted if there are mitigating factors indicating that the aquatic toxicity is unlikely to occur, for instance if the substance is highly insoluble in water (< 0.1 mg/l).
Solvent Brown 41 is therefore an insoluble substance for which no acute toxicity is possible to record at levels up to the water solubility , and which is not rapidly degradable in accordance with section 4.1.2.9.5. However, it has not a BCF > 500 or LgKow > 4 and therefore does not suggest potential to bioaccumulate in a long-term toxicity study.
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