Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 26027-38-3
Author:
Danish (Q)SAR Database
Year:
2016
Bibliographic source:
Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: predicted data
Principles of method if other than guideline:
Data is predicted using the Danish (Q)SAR Database
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3'-aminoacetophenone
EC Number:
202-722-3
EC Name:
3'-aminoacetophenone
Cas Number:
99-03-6
Molecular formula:
C8H9NO
IUPAC Name:
1-(3-aminophenyl)ethan-1-one
Details on test material:
- Name of test material: 3’-aminoacetophenone
- Molecular formula: C8H9NO
- Molecular weight: 135.16 g/mol
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No data available

Sampling and analysis

Analytical monitoring:
not specified
Details on sampling:
No data available

Test solutions

Vehicle:
not specified
Details on test solutions:
No data available

Test organisms

Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Details on test organisms:
No data available

Study design

Test type:
not specified
Water media type:
not specified
Total exposure duration:
72 h
Post exposure observation period:
No data available

Test conditions

Hardness:
No data available
Test temperature:
No data available
pH:
No data available
Dissolved oxygen:
No data available
Salinity:
No data available
Nominal and measured concentrations:
No data available
Details on test conditions:
No data available
Reference substance (positive control):
not specified

Results and discussion

Effect concentrations
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
30.649 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
not specified
Details on results:
No data available
Results with reference substance (positive control):
No data available
Reported statistics and error estimates:
No data available

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
Based on the QSAR prediction done using the Danish (Q)SAR Database, the EC50 was estimated to be 30.6495 mg/kg bw on Pseudokirchneriella s. for substance 3'-aminoacetophenone
Executive summary:

Based on the QSAR prediction done using the Danish (Q)SAR Database, the EC50 was estimated to be 30.6495 mg/kg bw on Pseudokirchneriella s. for substance 3'-aminoacetophenone.