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EC number: 202-722-3 | CAS number: 99-03-6
Mono- substituted aniline derivatives were tested for the induction of bacterial mutation using eight S typhimurium and two E coli strains. The gradient plate test for bacterial mutation was conducted with and without metabolic activation.All compounds were tested as supplied without further purification or attempt to identify impurities. Streptozotocin (STZ) (Sigma Chemical Company,St.Louis, MO) and 2-acetylaminofluorene (2-AAF) (Aldrich Chemical Company, Milwaukee, WI) served as positive controls for the bacterial mutation assay.
This test employed ten bacterial strains: eight histidine auxotrophs of S typhimurium (G46, TA 1535, TA100,C3076, TA1537, D3052, TA1538, and TA98) and two tryptophan auxotrophs of E coli (WP2 and WF2uvrA-). Each compound was incorporated into the top wedge of agar on each of four square plates to give a 10-fold concentration gradient per plate and thus provide a 10,000-fold concentration range for the compound. All tests were conducted with and without Aroclor 1254-induced rat liver S-9 and a maximum compound concentration of 1000 µg/ml of agar.
The results indicate the number of strains showing chemically induced revertant colonies as well as the concentration range over which mutation was observed in the most sensitive strain.
m-amino acetophenone exhibited mutagenic activity with and without metabolic activation in S typhimurium TA100, TA98,TA1538 strains
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