Registration Dossier
Registration Dossier
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EC number: 606-826-3 | CAS number: 217308-07-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Ames test
There are no studies available for (R)-ammonium mandelat, but for (R) – mandelic acid.
The substance (R) – mandelic acid was tested for its mutagenic potential in bacterial strains, i.e. Salmonella typhimurlium TA 1535, TA 100, TA 1537 and TA 98 and E. coli WP2 uvrA in a standard plate test (SPT) and preincubation test (PIT) with and without metabolic activation.
The dose range was 20 - 5000 µg/plate (SPT) and 4 – 2500 µg/pate (PIT). No precipitation of the test substance was found. A bacteriotoxic effeet was observed under all test conditions. An increase in the number of his+ or trp+ revertants was not observed in the standard plate test or in the preincubation test either without S-9 mix or after the addition of a metabolizing system. According to the results of the present study, the test substance ChiPros (R) –mandelic acid is not mutagenic in the Salmonella Typhimurium / Escherichia coli reverse mutation assay under the experimental conditions chosen here.[BASF, 2002]
Justification for selection of genetic toxicity endpoint
Only one study available
Short description of key information:
Ames (ChiPros (R)-mandelic acid): negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No need for classification according the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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