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Environmental fate & pathways

Endpoint summary

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Based on a calculated log Kow of >12.95 using a number of calculation models a BCF is calculated of 3.162 L/kg ww for tetramine diC16 -18. The calculated BCF indicates a low bioaccumulation potential. Tetramine diC16-18 is almost completely protonated under ambient conditions and will due to the strong sorption minimally bioavailable. The small bioavailable fraction is anticipated to be quickly degraded and a chronic exposure to a significant concentration is therefore unlikely. The predicted low bioaccumulation potential is supported by the low acute to chronic ratio observed in the short and long-term daphnia test. The long term daphnia test has an EC10 for reproduction of 0.148 mg/L where the short term test gave an EC50 of 0.244 mg/L for tetramine diC16 -18 resulting in a low acute-to-chronic ratio. A low acute-to-chronic ratio is indicative of a non-specific mode of action and is often associated with non-systemic effects. This observation is consistent with the known effects of cationic surfactants on aquatic organisms, where toxicity is associated with physical binding to respiratory membranes. This explains the steep concentration curves seen and the lack of intermediate chronic effects on reproduction.