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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 30, 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
other: UV-Vis spectrophotometer
Type:
Pow
Partition coefficient:
ca. 0.116
Temp.:
20 °C
pH:
ca. 5.95
Remarks on result:
other: Std. dev. 0.0231
Type:
log Pow
Partition coefficient:
ca. -0.946
Temp.:
20 °C
pH:
ca. 5.95
Remarks on result:
other: Std. dev. 0.085
Conclusions:
Pow = 0.1155
LogPow = -0.9462
Executive summary:

Method: 

Partition coefficient was determined by means of shake flask method as per recommendations of OECD Guideline 107. Partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting in two largely immiscible solvents.

 

Result:

Study conducted at 20 °C and at pH of 5.95

The average Pow is 0.1155

The average logPow is -0.9462

Description of key information

logPow = -0.9462

Study conducted at 20 °C and at pH of 5.95.

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.946
at the temperature of:
20 °C

Additional information

Partition coefficient was determined by means of shake flask method as per recommendations of OECD Guideline 107.