Registration Dossier
Registration Dossier
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EC number: 289-612-9 | CAS number: 89957-91-5 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus bergamia risso, Rutaceae.
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
72h-ErL50: 11 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 11 mg/L
Additional information
The ecotoxicity of Bergamot oil towards Pseudokirchnerella subcapitata was investigated according to OECD guideline 201 under GLP. Algal cells were exposed to WAFs with nominal loading rates of 1.0. 3.2, 10, 32 and 100 mg/L and were observed for 72 hours. The 72h-NOErLR and 72h-ErL50 were found to be 10 and 31 mg/L respectively based on nominal concentrations.
It was calculated that one of the constituents in Bergamot oil, Bergamottin, might potentially contribute to the ecotoxicity of Bergamot oil cold pressed to such an extent, that it is not covered by the Bergamot oil quality tested. Therefore, read across is conducted to Lime oil cold pressed for the study with the highest toxicity (lowest EL50 value), which is the study with algae (72h-ErL50 of 11 mg/L). Due to the read-across purpose this study was given a reliability 2 rating, in accordance with the ECHA Practical guide #6 on the reporting of read-across in IUCLID. The justification for read across is provided in the attached background material of the chapter summary.
Thus, for Bergamot oil cold pressed, the 72h-ErL50 for algae is expected to be 11 mg/L. As this latter study has the lowest ErL50, this study is selected as key study.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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