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EC number: 407-770-0
CAS number: 61597-96-4
The test item ethyl lactate was tested in 25 human volunteers at a
concentration of 8 % in petrolatum and produced no sensitisation
reactions. By way of read-across, this may be considered as an
indication that lactate esters in general, including isobutyl-R-lactate,
do not entail a skin sensitisation hazard.
No data available for isobutyl-R-lactate. Based on structural
similarity, representing lactate esters with alkyl moieties of similar
length, available data on ethyl lactate (source substance) was also used
in a read-across approach. In the publication by Opdyke et al. (1982)
the results of a study performed by Kligman (1976) were referenced.
Kligman conducted a maximisation test (Kligman 1966) on 25 human
volunteers. The test item ethyl lactate was tested at a concentration of
8 % in petrolatum and produced no sensitisation reactions.
By way of read-across, this may be considered as an indication that
lactate esters in general, including isobutyl-R-lactate, do not entail a
skin sensitisation hazard.
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