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Environmental fate & pathways

Biodegradation in water: screening tests

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Administrative data

biodegradation in water: ready biodegradability
Type of information:
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The approach followed in order to evaluate the ready biodegradability is in accordance with what is outlined in the specific endpoint REACH guidance.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference Type:
other: estimation

Materials and methods

Principles of method if other than guideline:
Qualitative Structure Activity Relationships - screening
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Trisodium hydrogen [2-[[α-[[3-[[4-chloro-6-[ethyl[4-[[2-(sulphooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-2-hydroxy-5-sulphophenyl]azo]benzyl]azo]-4-sulphobenzoato(6-)]cuprate(4-)
EC Number:
EC Name:
Trisodium hydrogen [2-[[α-[[3-[[4-chloro-6-[ethyl[4-[[2-(sulphooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-2-hydroxy-5-sulphophenyl]azo]benzyl]azo]-4-sulphobenzoato(6-)]cuprate(4-)
Cas Number:
Molecular formula:
Trisodium hydrogen [2-[[α-[[3-[[4-chloro-6-[ethyl[4-[[2(sulphooxy)ethyl]sulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-2-hydroxy-5-sulphophenyl]azo]benzyl]azo] -4-sulphobenzoato(6-)]cuprate(4-)

Results and discussion

% Degradation
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction

Any other information on results incl. tables

The screening procedure has been performed using the chemical structure drawn with and without Na salts, for completeness sake.

Non-linear model prediction (BIOWIN 2): 0.0000; does not biodegrade fast.

Ultimate biodegradation timeframe prediction (BIOWIN 3): 0.4140

Biowin5 (MITI linear model): -2.1369

MITI non-linear model prediction (BIOWIN 6): 0.0000; does not biodegrade fast

Applicant's summary and conclusion

Interpretation of results:
other: expected as not readily biodegradable
Expected as not readily biodegradable.
Executive summary:

Based on the physical-chemical properties and based on the knowledge of its biodegradation pathway, the substance is not expected to be ready biodegradable. In order to support this conclusion the ready biodegradability was evaluated using calculation tools.

 The QSAR based screening criterion for identifying substances for persistency (P and vP) confirmed that the substance is expected to be persistent.


The substance is expected to be non-ready biodegradable.