Registration Dossier
Registration Dossier
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EC number: 201-642-6 | CAS number: 85-91-6
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from EPI Suite modelling database
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- BCFBAF Program (v3.01)
- GLP compliance:
- no
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- not specified
- Type:
- BCF
- Value:
- 33.3 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- other: estimated
- Conclusions:
- The estimated bioconcentration factor (BCF) for methyl N-methylanthranilate is 33.3 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that methyl N-methylanthranilate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
- Executive summary:
The estimated bioconcentration factor (BCF) for methyl N-methylanthranilate is 33.3 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that methyl N-methylanthranilate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
Reference
BCFBAF Program (v3.01) Results:
==============================
SMILES : O=C(OC)c(c(NC)ccc1)c1
CHEM : Benzoic acid, 2-(methylamino)-, methyl ester
MOL FOR: C9 H11 N1 O2
MOL WT : 165.19
--------------------------------- BCFBAF v3.01 --------------------------------
Summary Results:
Log BCF (regression-based estimate): 1.52 (BCF = 33.3 L/kg wet-wt)
Biotransformation Half-Life (days) : 0.096 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): 1.39 (BAF = 24.4 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 2.81
Equation Used to Make BCF estimate:
Log BCF = 0.6598 log Kow - 0.333 + Correction
Correction(s): Value
No Applicable Correction Factors
Estimated Log BCF = 1.522 (BCF = 33.3 L/kg wet-wt)
Description of key information
The estimated bioconcentration factor (BCF) for methyl N-methylanthranilate is 33.3 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that methyl N-methylanthranilate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
Key value for chemical safety assessment
- BCF (aquatic species):
- 33.3 L/kg ww
Additional information
The estimated bioconcentration factor (BCF) for methyl N-methylanthranilate is 33.3 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that methyl N-methylanthranilate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
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