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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
14 day Long term toxicity tests were carried out to test the toxic effects of 1Chloro-3-nitrobenzene on fresh water crustacean daphnia magna.
GLP compliance:
no
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No data available
Analytical monitoring:
not specified
Details on sampling:
- Concentrations:
26 mg/l and 4.5mg/l
Vehicle:
not specified
Details on test solutions:
No data available
Test organisms (species):
Daphnia magna
Details on test organisms:
TEST ORGANISM
- Common name: Water flea
Test type:
semi-static
Water media type:
freshwater
Total exposure duration:
14 d
Post exposure observation period:
- Renewal rate of test solution (frequency/flow rate): Daily
Hardness:
No data available
Test temperature:
No data available
pH:
No data available
Dissolved oxygen:
No data available
Salinity:
No data available
Nominal and measured concentrations:
No data available
Details on test conditions:
No data available
Reference substance (positive control):
not specified
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
22.1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: Immobilization
Duration:
14 d
Dose descriptor:
EC50
Effect conc.:
3.82 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: Immobilization
Details on results:
No data available
Results with reference substance (positive control):
No data available
Reported statistics and error estimates:
No data available
Validity criteria fulfilled:
not specified
Conclusions:
Based on the immobilization the LC50 and EC50 was determined to be 22.1mg/l and 3.82mg/l respectively. As it is a chronic study substance may not be classified.
Executive summary:

Long term toxicity study was conducted to test the effects of 1 chloro 3 nirobenzene on daphnia magna for 14 days .based on the immobilization the LC50 and EC50 was determined to be 22.1mg/l and 3.82mg/l respectively.

Description of key information

Based on the immobilization the LC50 and EC50 was determined to be 22.1 mg/l and 3.82 mg/l respectively. As it is a chronic study substance may not be classified.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
22.1 mg/L

Additional information

Based on the value aquired from peer reviewed journal,long term toxicity of aquatic invertebrates was discribed as below:

Long term toxicity study was conducted to test the effects of 1-chloro-3-nitrobenzene on daphnia magna for 14 days .Based on the immobilization the LC50 and EC50 was determined to be 22.1mg/l and 3.82mg/l respectively.

Long term toxicity study was conducted to test the effects of 1-chloro-3-nitrobenzene on fresh water invertebrates daphnia magna for 21 days. Feeding was provided to the daphnids 3x108C.pyrenoidosa cells/l/day.Based on the mortality the LC50 was determined to be 2.0mg/l for 21days chronic exposure. The substance may not be classified as it is chronic study.

Based on the effect concentrations we can consider that the test substance 1-chloro-3-nitrobenzene has no chronic effect on aquatic invertebrates and can be considered as not classified as per CLP.