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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal

Data source

Reference
Reference Type:
secondary source
Title:
TOXICOLOGICAL EVALUATION
Author:
BG Chemie
Year:
2000
Bibliographic source:
BG Chemie InfoCenter TOXIKOLOGISCHE BEWERTUNGEN, last updated 11/2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study was conducted to test the effects of m chloronitrobenzene on new Zealand rabbits after 24 hr.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-3-nitrobenzene
EC Number:
204-496-1
EC Name:
1-chloro-3-nitrobenzene
Cas Number:
121-73-3
Molecular formula:
C6H4ClNO2
IUPAC Name:
1-chloro-3-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): 1-chloro-3-nitrobenzene
- Molecular formula (if other than submission substance): C6H4ClNO2
- Molecular weight (if other than submission substance): 157.556 g/mol
- Smiles notation: c1(cc(ccc1)Cl)[N+](=O)[O-]
- InChl : 1S/C6H4ClNO2/c7-5-2-1-3-6(4-5)8(9)10/h1-4H
- Substance type: Solid
- Physical state: Organic
- Impurities (identity and concentrations): No data

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
other: semi-occlusive bandage with adhesive plaster
Preparation of test site:
not specified
Vehicle:
other: 0.3 ml propylene glycol
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
30 and 60 minutes
Observation period:
24hr
Number of animals:
3 animals
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24hrs
Remarks on result:
other: Non irritating, Hardly noticeable erythema
Irritant / corrosive response data:
No data available
Other effects:
No data available

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
m-Chloronitrobenzene was found to be non- irritating to skin.
Executive summary:

m-Chloronitrobenzene was applied as a paste made with 0.3 ml propylene glycol, and covered with a semi-occlusive bandage which was affixed to the application site with ad-hesive plaster. Following the exposure period, the chemical was removed from the skin with lukewarm water. Assessments of the treated area of skin after 30 and 60 minutes revealed mild, hardly noticeable erythema in 2 animals. After 24 hours, the animals no longer showed any signs of irritation. Therefore, m-chloronitrobenzene was not irritating to the rabbit skin .