Registration Dossier
Registration Dossier
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EC number: 201-184-7 | CAS number: 79-19-6
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis:
The Hydrolysis rate constant of Thiosemicarbazide, is estimated to be 0.000000000084 cm3/molecule-sec at half-life of 1.528 hrs. The estimated half-life of the substance indicates that the substance Thiosemicarbazide, is rapidly hydrolysable.
Biodegradation
Biodegradation in water: screening tests
The screening test inherent to the biodegradability of the substance was calculated using the software BIOWIN v4.10. The results indicate that Thiosemicarbazide,is not expected to be readily biodegradable.
In the supporting study, biodegradation screening test was done for 4 weeks by using BOD, TOD and HPLC methods. Initial concentration of thiosemicarbazide is 100 ppm and concentration of inoculum (sludge) is 30 ppm. The test substance found to be 0% degradable after 4 weeks.
Biodegradation in water and sediment: simulation tests
Half-life period of Thiosemicarbazide, in water is observed to be 15 days (360 hrs.) while in sediment it is 135 days (3240 hrs). Based on these half-life values of Thiosemicarbazide, it is concluded that the chemical is not persistent in water and sediment.
Biodegradation in soil
EPI Suite has estimated Thiosemicarbazide, is expected to be found predominantly in soil and it’s persistence estimate is based on its transformation in this medium. Its half-life in soil, 30 days (720 hrs), does exceeds the threshold of 120 days as per Annex XIII of REACH regulation.
Therefore, Thiosemicarbazide, is estimated to be not persistent in the soil environment.
Bioaccumulation:
The estimated bioconcentration factor (BCF) for Thiosemicarbazide, is 3.162 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that Thiosemicarbazide,is not expected to bioaccumulate in the food chain.
In the supporting study, BCF factor was found to be < 3.8 - 4.2 at concentration of 0.4mg/L and <39 L/kg at concentration 0.04 mg/L in Cyprinus carpio during a 6 week exposure.
Transport and distribution:
Adsorption / desorption
The soil adsorption coefficient (Koc) value of Thiosemicarbazide, is estimated to be 16.33 L/kg, indicating that it is has a low sorption to soil and sediment and therefore have significant migration potential to groundwater.
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