Registration Dossier
Registration Dossier
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EC number: 201-184-7 | CAS number: 79-19-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There is no information available pertaining to the toxicokinetic or pharmacokinetic data for the target chemical 1-amino-2-thiourea. Occupational exposure to 1-amino-2-thiourea may occur through inhalation of dust and dermal contact with this compound at workplaces where 1-amino-2-thiourea is produced or used. Based upon the physico-chemical properties like high water solubility of the chemical (1X10+4 mg/L at 20 deg C) and low octanol/water partition co-efficient value (log Kow = -1.67 (est) and low bioconcentration factor (BCF), it may be concluded that the chemical shall have limited bio-availability within the living system. But the acute oral effects like darkened liver, suggest adverse effects probably due to the accumulation of the chemical. Thus, considering the available information in this report the bio-accumulation potential for 1-amino-2-thiourea cannot be judged.
Key value for chemical safety assessment
Additional information
There is no information available pertaining to the toxicokinetic or pharmacokinetic data for the target chemical1-amino-2-thiourea.Occupational exposure to 1-amino-2-thiourea may occur through inhalation of dust and dermal contact with this compound at workplaces where 1-amino-2-thiourea is produced or used. Based upon the physico-chemical properties likehigh water solubility of the chemical (1X10+4 mg/L at 20 deg C) and low octanol/water partition co-efficient value (log Kow = -1.67 (est) and low bioconcentration factor (BCF), it may be concluded that the chemical shall have limited bio-availability within the living system. But the acute oral effects like darkened liver, suggest adverse effects probably due to the accumulation of the chemical. Thus, considering the available information in this report the bio-accumulation potential for1-amino-2-thiourea cannot be judged.
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