Registration Dossier
Registration Dossier
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EC number: 201-184-7 | CAS number: 79-19-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice
- Author:
- E. W. Schafer, Jr. and W. A. Bowles, Jr
- Year:
- 1 985
- Bibliographic source:
- Arch. Environ. Contain. Toxicol. 14, 111-129, 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- An acute oral toxicity study was conducted to evaluate toxicity of Thiosemicarbazide in deer mice
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- yes
Test material
- Reference substance name:
- Thiosemicarbazide
- EC Number:
- 201-184-7
- EC Name:
- Thiosemicarbazide
- Cas Number:
- 79-19-6
- Molecular formula:
- CH5N3S
- IUPAC Name:
- hydrazinecarbothioamide
- Details on test material:
- - Name of test material (as cited in study report): Thiosemicarbazide
- Molecular formula (if other than submission substance): CH5N3S
- Molecular weight (if other than submission substance): 91.1375 g/mol
- Substance type: Organic
- Physical state: Solid
- Analytical purity: No data available
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Peromyscus maniculatus
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wild-trapped house and deer mice
or domestically bred house mice were used
- Age at study initiation: No data available
- Weight at study initiation: 20 g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): Wheat seeds
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Water, corn oil, or 1.0% carbopol
- Details on oral exposure:
- No detailed data about vehicle available
- Doses:
- Dosing details not available
- No. of animals per sex per dose:
- 6 animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 3 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: Mortality was observed - Statistics:
- Method of Thompson (1948) and Thompson and Weil (1952)
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 94 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) for the test compound thiosemicarbazide is found to be 94.0 mg/kg in deer mice.
- Executive summary:
An acute oral toxicity study was conducted to evaluate toxicity ofThiosemicarbazidein deer mice.
The chemical was administered by gavage using water, corn oil, or 1.0% carbopol as carriers, followed by 3-days of observations for mortality.
The acute oral median lethal dose (LD50) for the test compound thiosemicarbazide is found to be 94.0 mg/kg.
According to the publication, the test materialThiosemicarbazide classifies as an acute oral toxicant Category 3 chemical.
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