Thiosemicarbazide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from publication

Data source

Reference

Reference Type:

publication

Title:

Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice

Author:

E. W. Schafer, Jr. and W. A. Bowles, Jr

Year:

1985

Bibliographic source:

Arch. Environ. Contain. Toxicol. 14, 111-129, 1985

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

An acute oral toxicity study was conducted to evaluate toxicity of Thiosemicarbazide in deer mice

GLP compliance:

not specified

Test type:

other: No data available

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Thiosemicarbazide

EC Number:

201-184-7

EC Name:

Thiosemicarbazide

Cas Number:

79-19-6

Molecular formula:

CH5N3S

IUPAC Name:

hydrazinecarbothioamide

Details on test material:

- Name of test material (as cited in study report): Thiosemicarbazide
- Molecular formula (if other than submission substance): CH5N3S
- Molecular weight (if other than submission substance): 91.1375 g/mol
- Substance type: Organic
- Physical state: Solid
- Analytical purity: No data available

Test animals

Species:

mouse

Strain:

other: Peromyscus maniculatus

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Wild-trapped house and deer mice
or domestically bred house mice were used
- Age at study initiation: No data available
- Weight at study initiation: 20 g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): Wheat seeds
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: No data available

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Water, corn oil, or 1.0% carbopol

Details on oral exposure:

No detailed data about vehicle available

Doses:

Dosing details not available

No. of animals per sex per dose:

6 animals

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 3 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: Mortality was observed

Statistics:

Method of Thompson (1948) and Thompson and Weil (1952)

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

94 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute oral median lethal dose (LD50) for the test compound thiosemicarbazide is found to be 94.0 mg/kg in deer mice.

Executive summary:

An acute oral toxicity study was conducted to evaluate toxicity ofThiosemicarbazidein deer mice.

 

The chemical was administered by gavage using water, corn oil, or 1.0% carbopol as carriers, followed by 3-days of observations for mortality.

 

The acute oral median lethal dose (LD50) for the test compound thiosemicarbazide is found to be 94.0 mg/kg.

 

According to the publication, the test materialThiosemicarbazide classifies as an acute oral toxicant Category 3 chemical.