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EC number: 201-184-7 | CAS number: 79-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Thiosemicarbazide is not irritating to the skin of male CD rats and to the eyes of New Zealand White rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: Draize method
- Principles of method if other than guideline:
- Range finding study was conducted to evaluate the skin irritation potential of the test compound Thiosemicarbazide
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- other: CD
- Details on test animals or test system and environmental conditions:
- Sex: Male
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- physiological saline
- Remarks:
- 0.85% saline, 1:1
- Controls:
- not specified
- Amount / concentration applied:
- 0, 20, and 200 mg/kg
- Duration of treatment / exposure:
- 24 hrs
- Observation period:
- 14 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: No data available
- % coverage: No data available
- Type of wrap if used: No data available
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: No data available
SCORING SYSTEM: No data available - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 14 days
- Reversibility:
- no data
- Remarks on result:
- other: Dermal irritation not observed
- Other effects:
- Mortality was observed on day 1 of 14 day post treatment and 1 on the day of treatment
Convulsions, tremors, salivation, aggressiveness, and red stained muzzle were observed in the decedent rats. Terminal necropsy disclosed wet and/or tan or red-stained muzzles and darkened livers. - Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Thiosemicarbazide is not irritating to the skin of male CD rats.
- Executive summary:
Thiosemicarbazide was evaluated in range-finding study for acute dermal toxicity in male CD rats administered single occluded dermal applications (0.85% saline, 1:1) of 0, 20, and 200 mg/kg for 24 hours.
Dermal exposure was associated with mortality in 5/6 high dose rats only, 4 on Day 1 of 14-day post-treatment observation and 1 on the day of treatment. Prior to death, the decedent rats unanimously exhibited convulsions, tremors, salivation, aggressiveness, and red stained muzzle. Terminal necropsy disclosed wet and/or tan or red-stained muzzles and darkened livers. No apparent toxicity was reported among the solitary surviving rat of a 200 mg/kg application or rats of a 20 mg/kg dose, and no dermal irritation (Draize) was noted in any treated animal.
Thiosemicarbazide is not irritating to the skin of male CD rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Range finding study was conducted to evaluate the eye irritation potential of the test compound Thiosemicarbazide
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Sex: Male
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- Duration of treatment: 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): ): 20- 30 sec after the exposure in 3/6 male rabbits
- Time after start of exposure:
SCORING SYSTEM: Ocular irritation of cornea, iris, conjunctivae
TOOL USED TO ASSESS SCORE: No data - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 days
- Reversibility:
- not specified
- Remarks on result:
- other: No ocular irritation (Draize) of cornea, iris, or conjunctivae was observed.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Thiosemicarbazide is not irritating to the eyes of New Zealand White rabbits.
- Executive summary:
Eye irritation study was performed male New Zealand White rabbits to evaluate the irritation potential of the test compound Thiosemicarbazide.
The test chemical was instilled as a single dose of 0.1g in the eyes of rabbits. Half (3/6) of the eyes were cleansed at 20-30 seconds after the exposure.
No ocular irritation (Draize) of cornea, iris, or conjunctivae was reported in any animal throughout 7-day post-instillation observation.
Thiosemicarbazide is not irritating to the eyes of New Zealand White rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
Thiosemicarbazide was evaluated in range-finding study for acute dermal toxicity in male CD rats administered single occluded dermal applications (0.85% saline, 1:1) of 0, 20, and 200 mg/kg for 24 hours.
Dermal exposure was associated with mortality in 5/6 high dose rats only, 4 on Day 1 of 14-day post-treatment observation and 1 on the day of treatment. Prior to death, the decedent rats unanimously exhibited convulsions, tremors, salivation, aggressiveness, and red stained muzzle. Terminal necropsy disclosed wet and/or tan or red-stained muzzles and darkened livers. No apparent toxicity was reported among the solitary surviving rat of a 200 mg/kg application or rats of a 20 mg/kg dose, and no dermal irritation (Draize) was noted in any treated animal.
Thiosemicarbazide is not irritating to the skin of male CD rats.
In accordance with the CLP classification, the test material Thiosemicarbazide does not classify as a skin irritant.
Eye irritation:
Eye irritation study was performed male New Zealand White rabbits to evaluate the irritation potential of the test compoundThiosemicarbazide.
The test chemical was instilled as a single dose of 0.1g in the eyes of rabbits. Half (3/6) of the eyes were cleansed at 20-30 seconds after the exposure.
No ocular irritation (Draize) of cornea, iris, or conjunctivae was reported in any animal throughout 7-day post-instillation observation. Thiosemicarbazide is not irritating to the eyes of New Zealand White rabbits.
In accordance with the CLP classification, the test material Thiosemicarbazide does not classify as an eye irritant.
Justification for selection of skin irritation / corrosion endpoint:
Thiosemicarbazide is not irritating to the skin of male CD rats.
Justification for selection of eye irritation endpoint:
Thiosemicarbazide is not irritating to the eyes of New Zealand White rabbits.
Justification for classification or non-classification
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