Registration Dossier
Registration Dossier
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EC number: 259-210-8 | CAS number: 54546-26-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- The study was conducted in 1977.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was administered orally to 10 rats at 5 g/kg.
- GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 2-butyl-4,4,6-trimethyl-1,3-dioxane
- EC Number:
- 259-210-8
- EC Name:
- 2-butyl-4,4,6-trimethyl-1,3-dioxane
- Cas Number:
- 54546-26-8
- Molecular formula:
- C11H22O2
- IUPAC Name:
- 2-butyl-4,4,6-trimethyl-1,3-dioxane
- Test material form:
- not specified
- Details on test material:
- - Name of test material: 77-208; herboxane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- Ten, sex not specified.
- Control animals:
- no
- Details on study design:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- There was no mortality during the study.
- Clinical signs:
- Piloerection, slight lethargy and ataxia.
- Gross pathology:
- Observations at necropsy included a large spleen in one animal and hernia (probably not related to the test substance) in one rat.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of the test substance was > 5.0 g/kg bodyweight.
- Executive summary:
The test substance was administered orally to 10 rats at 5 g/kg. The acute oral LD50 of the test substance was > 5.0 g/kg bodyweight.
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