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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
The study was conducted in 1977.
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test substance was administered orally to 10 rats at 5 g/kg.
GLP compliance:
no
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-butyl-4,4,6-trimethyl-1,3-dioxane
EC Number:
259-210-8
EC Name:
2-butyl-4,4,6-trimethyl-1,3-dioxane
Cas Number:
54546-26-8
Molecular formula:
C11H22O2
IUPAC Name:
2-butyl-4,4,6-trimethyl-1,3-dioxane
Test material form:
not specified
Details on test material:
- Name of test material: 77-208; herboxane

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data
Doses:
5 g/kg
No. of animals per sex per dose:
Ten, sex not specified.
Control animals:
no
Details on study design:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
not specified
Mortality:
There was no mortality during the study.
Clinical signs:
Piloerection, slight lethargy and ataxia.
Gross pathology:
Observations at necropsy included a large spleen in one animal and hernia (probably not related to the test substance) in one rat.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 of the test substance was > 5.0 g/kg bodyweight.
Executive summary:

The test substance was administered orally to 10 rats at 5 g/kg. The acute oral LD50 of the test substance was > 5.0 g/kg bodyweight.