Registration Dossier
Registration Dossier
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EC number: 701-242-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
LD50 (dermal) > 2000 mg/kg bw
LC50 (inhalation > 18.3 mg/L
Key value for chemical safety assessment
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 18.3 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute toxicity of Reaction Products of C4 alcohols and C4 alkenes obtained as by-products from the manufacturing of butan-2-ol by sulfuric acid esterification and hydrolysis of butene was investigated in an acute inhalation toxicity study and an acute dermal toxicity study.
No deaths occurred in a group of six rats exposed to a mean achieved atmosphere concentration of 18.3 mg/L for four hours. It was therefore considered that the acute inhalation median lethal concentration (4 hr LC50) of Reaction Products of C4 alcohols and C4 alkenes obtained as by-products from the manufacturing of butan-2-ol by sulfuric acid esterification and hydrolysis of butene, in the HsdHanTM : WIST strain rat, was greater than 18.3 mg/L.
The acute dermal median lethal dose (LD50) of the test material in the Wistar strain rat was found to be greater than 2000 mg/kg bodyweight.
Altogether the acute toxicity data show that Reaction Products of C4 alcohols and C4 alkenes obtained as by-products from the manufacturing of butan-2-ol by sulfuric acid esterification and hydrolysis of butene is of low acute toxicity and does not require classification for this endpoint.
Justification for classification or non-classification
Acute Toxicity: The substance does not meet the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) NO. 1272/2008.
Specific target organ, Neurotoxicity: According to CLP classification criteria, the substance does meet the criteria for classification and labelling for this endpoint (STOT single exposure category 3, H336 - May cause drowsiness or dizziness), as set out in Regulation (EC) No. 1272/2008.
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