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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

Although ready biodegradability of the 2-methylpyridine isomer has not been confirmed in a guideline study, evidence supports the determination that 2-methylpyridine is readily biodegradable in the environment.  The OECD Guideline 301B test by Weytjens and Wils (1991) shows that 3-methylpyridine is readily biodegradable. The ready biodegradability determination for 3-methylpyridine is representative of the methylpyridine isomers in the chemical category, which includes pyridine, 2-methylpyridine, 3-methylpyridine and 4-methylpyridine. 

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

The determination of the ready biodegradability of 2-methylpyridine is supported by the results of the non-guideline study by Pandey and Sandhya (1997), which showed 96% TOC removal in 48 hours at a test substance concentration of 12.5 mg 2-methylpyridine/L. In addition, the results of the non-guideline assay by Japan MITI (1992) demonstrated ready biodegradability (58% biodegradation by BOD in 3 weeks and on upward trend) of 2 -methylpyridine at a test substance concentration of 100 mg 2-methylpyridine/L.

2-Methylpyridine (alpha-picoline, CAS 109-06-8) is a member of a category with is utilized for “read-across” to fill data gaps and for risk assessment for hazard identification. The category of pyridine and alkyl pyridine derivatives is comprised of pyridine (CAS 110 -86 -1), 2-methylpyridine (CAS 109-06-8), 3-methylpyridine (CAS 108-99-6) and 4-methylpyridine (CAS 108-89-4). The foundation of the category is a common functional group (the pyridine unsaturated ring structure) and similar physico-chemical properties, environmental fate and toxicity, and mammalian toxicity. Similar ecotoxicological and environmental fate properties derive from physico-chemical parameters and common pathways of metabolism and elimination among all members of the category. Three of four members of this category have harmonized classification and labelling. Read-across for non-harmonized endpoints is adequate for risk assessment purposes.