2-methylpyridine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: similar to guideline study, but prior to establishment of guideline protocols and GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

was conducted prior to establishment of guideline method

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylpyridine

EC Number:

203-643-7

EC Name:

2-methylpyridine

Cas Number:

109-06-8

Molecular formula:

C6H7N

IUPAC Name:

2-methylpyridine

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 h

Doses:

79.4, 200, 316, 501, 1000 and 2000 mg/kg bw

No. of animals per sex per dose:

1

Control animals:

no

Details on study design:

gross necropsy on animals which succumbed during study and on surviving animals sacrificed after the conclusion of the experiment.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 200 - < 316 mg/kg bw

Based on:

test mat.

Mortality:

Animals given 79.4 and 200 mg/kg bw survived. Animals given 316 and 501 mg/kg bw died after 1 day, and those given 1000 and 2000 mg/kg bw died after 16 hours.

Clinical signs:

other: reduced appetite and activity, rapidly increasing weakness, collapse and death

Gross pathology:

hemorrhagic lungs, slightly discolored liver and gastrointestinal inflammation. There were no abnormalities in surviving animals.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

An acute dermal toxicity test was conducted using occlusive exposure conditions using one albino rabbit at each of six doses of 2-methylpyridine. The LD50 was greater than 200 and less than 316 mg/kg bw.