Registration Dossier
Registration Dossier
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EC number: 201-846-5 | CAS number: 88-63-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from authorative handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity study of 1,3-Phenylenediamine-4-sulfonic acid in rat
- Author:
- Richard J Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax’s Dangerous Properties of Industrial Materials, 12th Edition
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- Acute oral toxicity study of 1,3-Phenylenediamine-4-sulfonic acid in rat.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4-diaminobenzenesulphonic acid
- EC Number:
- 201-846-5
- EC Name:
- 2,4-diaminobenzenesulphonic acid
- Cas Number:
- 88-63-1
- Molecular formula:
- C6H8N2O3S
- IUPAC Name:
- 2,4-diaminobenzenesulphonic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material: 2,4-Diaminobenzenesulfonic acid- Molecular formula: C6H8N2O3S- Molecular weight : 188.206 g/mol- Smiles notation: O=S(=O)(O)c1c(N)cc(N)cc1- InChl : 1S/C6H8N2O3S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,7-8H2,(H,9,10,11)- Substance type: Organic- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 3480 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 480 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- No data available
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Acute oral LD50 value of 1,3-Phenylenediamine-4-sulfonic acid is considered to be 3480 mg/kg in rat.
- Executive summary:
Acute oral toxicity test of 1,3-Phenylenediamine-4-sulfonic acid was conducted with rat in the concentration of 3480 mg/kg mg/kg bw orally. 50 % mortality was observed in treated rat. Therefore, LD50 was considered to be 3480 mg/kg when rats were treated with 2,4-diaminobenzenesulphonic acid orally.
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