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EC number: 247-668-1 | CAS number: 26402-26-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- EG guideline 84/449/EWG
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The poorly soluble test substance was added to synthetic freshwater at 1 g/L and stirred for 18 hours. Afterwards the solution was filtrated. This solution was used as stock solution. The DOC content was determined to be 2.95 mg/L, equivalent to a test substance content of 4.38 mg/L. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Waterflea
- Strain: Straus, clone 5
- Source: own breeding
- Age at study initiation: < 24 hours
- Method of breeding: parthogenetic reproduction
- Feeding during test: none
ACCLIMATION/CULTURE
- Culture conditions: M4 medium according to Elendt, 1 L beakers
- Type and amount of food: Scenedesmus subspicatus, as much as they eat
- Feeding frequency: daily
- Health during acclimation: healthy, darkbrown colour - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20 +/- 1°C
- pH:
- 7.6 - 8.1
- Dissolved oxygen:
- 7.5 - 7.6 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 0.53, 0.70, 1.01, 1.40, 2.01, 2.80, 3.94 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: Beakers filled with 10 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 2 mL per test organism
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: synthetic freshwater (CaCl2xH2O: 294 mg/L; MgSO4x7H2O: 123 mg/L; NaHCO3: 63 mg/L; KCl: 5.5 mg/L)
OTHER TEST CONDITIONS
- Photoperiod: dark
EFFECT PARAMETERS MEASURED: Immobilisation, after 24 and 48 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: < 2 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 3.94 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: No effect up to the limit of the water solubility of the test substance was observed.
- Details on results:
- - Mortality of control: none
- Any observations that might cause a difference between measured and nominal values: No, as stock solution was filtered and thus, the highest tested concentration was the highest water soluble concentration of the test substance. - Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 8. to 10. November 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- . Additionally consideration of the "VCI-Konzept-Entwurfes für die (akute) aquatische Prüfung von schwerlöslichen Stoffen vom 31.1. 1994"
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: both test runs (a) directly weighed in and b) separated from undissolved test substance and)
- Sampling method: Samples were taken at 0 and 48 hours - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Due to the low solubility of the test substance, two different test solutions were prepared according to the VCI-concept for poorly soluble substances.
a) 100 mg/L directly weighed in solution: The test substance was directly weighed into the vessel and ultrasonicated for 5 min.
b) Test solution with 100 mg/L and subsequently separation of unsolved test substance: 100 mg test substance were added to 1 L M4 medium and stirred for 24h. Afterwards the unsolved test substance was separated by filtration with a fibre glass filter (pretreated with 1 molar NaOH). - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain: STRAUS
- Source: BGA Berlin (May 1994) afterwards own breeding
- Age at study initiation (mean and range, SD): 6 - 24h
- Feeding during test: none
ACCLIMATION
- Type and amount of food: Scenedesmus subspicatus - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 21.8°C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 94% oxygen saturation
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
Measured concentrations:
Test solution a) directly weighed in without separation: 0h = 79.33 mg/L; 48h = 26.76 mg/L
Test solution b) separation of undissolved matter: 0h = 2.33 mg/L; 48 h = 0.08 mg/L The recovery of the test substance at the beginning and after 48 hours was higher than the water solubility of the test substance determined with the column elution method, what means that the separation was not complete. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 100 mL glass beaker, covered with a glass disc and filled with 50 mL
- Aeration: no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 5 mL per daphnia
TEST MEDIUM / WATER PARAMETERS
- Test medium: M4-medium according to guideline
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours
EFFECT PARAMETERS MEASURED: Immobilisation
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit test - only 100 mg/L - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: solution a) test substance directly weighed in without separation of undissolved matter
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.01 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: solution b) separation of undissolved matter: No effect up to the limit of the water solubility of test substance (< 0.01 mg/L).
- Details on results:
- - Mortality of control: none
- Any observations that might cause a difference between measured and nominal values: Yes, for solution a) a turbidity of the test suspension was observed.
- Effect concentrations exceeding solubility of substance in test medium: yes, for solution a) without separation of undissolved test substance - Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 8. to 10. November 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- . Additionally consideration of the "VCI-Konzept-Entwurfes für die (akute) aquatische Prüfung von schwerlöslichen Stoffen vom 31.1. 1994"
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: both test runs (a) directly weighed in and (b) separated from undissolved test substance
- Sampling method: Samples were taken at 0 and 48 hours - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Due to the low solubility of the test substance two different test solutions were prepared according to the VCI-concept for poorly soluble substances.
a) 100 mg/L directly weighed in solution: The test substance was directly weighed into the vessel and ultrasonicated for 5 min.
b) Test solution with 100 mg/L and subsequently separation of unsolved test substance: 100 mg test substance were added to 1 L M4 medium and stirred for 24h. Afterwards the unsolved test substance was separated by filtration with a fibre glass filter (pretreated with 1 molar NaOH). - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain: STRAUS
- Source: BGA Berlin (May 1994) afterwards own breeding
- Age at study initiation: 6 - 24h
- Feeding during test: none
HOUSING
- Type and amount of food: Scenedesmus subspicatus - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 21.8°C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- at least 90% oxygen saturation
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
Measured concentrations:
Test solution a) directly weighed in without separation: 0h = 105.36 mg/L; 48h = 44.30 mg/L
b) separation of undissolved matter: 0h = 0.29 mg/L; 48 h = 0.15 mg/L The recovery of the test substance at the beginning and after 48 hours was higher than the water solubility of the test substance determined with the column elution method, what means that the separation was not complete. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 100 mL glass beaker, covered with a glass disc and filled with 50 mL
- Aeration: no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 5 mL per daphnia
TEST MEDIUM / WATER PARAMETERS
- Test medium: M4-medium according to guideline
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilisation
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit test - only 100 mg/L - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: solution a) test substance directly weighed in without separation of undissolved matter: No effect up to the limit of the water solubility of the test substance was observed.
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.01 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: solution b) separation of undissolved matter: No effect up to the limit of the water solubility of test substance (< 0.01 mg/L).
- Details on results:
- - Mortality of control: none
- Any observations that might cause a difference between measured and nominal values: Yes, for solution a). Black particles were observed in the suspension. Partly they adhered on the daphnids. A turbidity of the test suspension was observed.
- Effect concentrations exceeding solubility of substance in test medium: yes, for solution a) without separation of undissolved test substance - Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 13.-15. October 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L (Limit test)
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 100 mg/L of the test substance were weighed into test medium and stirred for one day. Following the stock solution was filtered with a fibre glass filter (pretreated with NaOH). The filtrate was used as test solution.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): No, not after filtration. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: BioInternational B.V., NJ Horn, the Netherlands
- Method of breeding: Ephippien delivered at 1998-09-03. They were incubated at approx. 20°C with continuous light (approx. 4800 lux) in a M4-Medium (Elendt)
- Feeding during test: none
ACCLIMATION
- Acclimation period: The hatched neonates were kept at approx. 20°C with 16hours light (900 Lux) in a M4-Medium (Elendt).
- Acclimation conditions (same as test or not): yes, same as test conditions
- Type and amount of food: Scenedesmus subspicatus - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 20-20.2°C
- pH:
- 8.0
- Dissolved oxygen:
- 92-94% oxygen saturation
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L (prepared as WAF)
Measured concentration: Recovery < 1% - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 100 mL glass beaker, filled with 50 mL and covered with glass plates
- Aeration: no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Intervals of water quality measurement: after 48h
OTHER TEST CONDITIONS
- Adjustment of pH: not mentioned
- Photoperiod: 16h light / 8h dark
- Light intensity: approx. 900 lux
EFFECT PARAMETERS MEASURED: Immobilisation after 24 and 48 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit test - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: No effect up to the limit of the water solubility of the test substance was observed.
- Details on results:
- - Mortality of control: No
- Other adverse effects control: no
- Effect concentrations exceeding solubility of substance in test medium: yes, but test solution was prepared as Water Accomodated Fraction (WAF) and thus no undissolved test substance was present in test solution. - Results with reference substance (positive control):
- The EC50 (24h) with potassium dichromate was between 0.9 and 1.9 mg/L (here 1.4 mg/L) and fulfils therewith the validity criteria.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance.
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- refer to category justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: RA CAS 97722-02-6
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.01 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: RA CAS 67701-30-8
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.01 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: RA CAS 65381-09-1
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 3.94 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: RA CAS 620-67-7
Referenceopen allclose all
No effect up to the limit of the water solubility of the test substance was observed.
Table 1: Cumulative numbers of immobilised individuals during the test, absolute and % readings
Concentration (mg/L) |
24h values |
48h values |
||||
mobile |
immobile |
immobile % |
mobile |
immobile |
immobile % |
|
Control |
20 |
0 |
0 |
20 |
0 |
0 |
0.53 |
20 |
0 |
0 |
19 |
1 |
5 |
0.70* |
21 |
0 |
0 |
21 |
0 |
0 |
1.01 |
19 |
1 |
5 |
19 |
1 |
5 |
1.40 |
20 |
0 |
0 |
20 |
0 |
0 |
2.01* |
21 |
0 |
0 |
21 |
0 |
0 |
2.80 |
20 |
0 |
0 |
20 |
0 |
0 |
3.94 |
19 |
1 |
5 |
19 |
1 |
5 |
* 21 daphnids used in test
No effect was observed up to the limit of the water solubility of the test substance under conditions tested. For the test solution a) without the separation of the undissolved test substance, an immobilisation of 20 to 30% (mean 25%) was observed.
Table 1: Immobilisation (%) of daphnids in solution a) (without separation of undissolved test substance)
Concentration (mg/L) |
Incubation time (h) |
|
24 |
48 |
|
0/1 |
0 |
0 |
0/2 |
0 |
0 |
100/1 |
0* |
20* |
100/2 |
10* |
30* |
*Daphnia swimming on the surface, caught in oil drops. A turbidity of the test suspension was observed.
Table 2: Immobilisation (%) of daphnids in solution b) (with separation of undissolved test substance)
Concentration (mg/L) |
Incubation time (h) |
|
24 |
48 |
|
0/1 |
0 |
0 |
0/2 |
0 |
0 |
100/1 |
0 |
0 |
100/2 |
0 |
0 |
No effect was observed up to the limit of the water solubility of the test substance under conditions tested. Furthermore no effects were observed in an oversaturated solution with undissolved test substance.
Table 1: Immobilisation (%) of daphnids in solution a) (without separation of undissolved test substance)
Concentration (mg/L) |
Incubation time (h) |
|
24 |
48 |
|
0/1 |
0 |
0 |
0/2 |
0 |
0 |
100/1 |
0* |
10* |
100/2 |
10* |
10* |
*Black particles were observed in the suspension. Partly, they adhered on the daphnids. A turbidity of the test suspension was observed.
Table 2: Immobilisation (%) of daphnids in solution b) (with separation of undissolved test substance)
Concentration (mg/L) |
Incubation time (h) |
|
24 |
48 |
|
0/1 |
0 |
0 |
0/2 |
0 |
0 |
100/1 |
0 |
0 |
100/2 |
0 |
0 |
The test solutions were prepared as Water Accomodated Fraction (WAF) by filtrating the undissolved test material out.
In this test no effect up to the limit of the water solubility of the test substance was observed.
The test report mentions a EC50, but due to the fact that WAFs were prepared a EL50 has to be reported instead.
Description of key information
No effect on aquatic invertebrates up to the limit of the water solubility of Fatty Acid Glycerides was observed (EC50 > water solubility).
Key value for chemical safety assessment
Additional information
The hazard assessment is based on the data currently available. New studies (including long-term studies) with the registered substance will be conducted in the future. The finalised studies will be included in the technical dossier as soon as they become available and the hazard assessment will be re-evaluated accordingly.
In order to fulfil the standard information requirements, according to Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from structurally related substances was conducted. According to Article 13 of Regulation (EC) No. 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of substances", Information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met. Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. This avoids the need to test every substance for every endpoint”.
Four short-term studies with Daphnia magna are available for four different substances (CAS 97722-02-6, CAS 67701-30-8, CAS 620-67-7 and CAS 65381-09-1). In all four static studies over 48 hours no effect on Daphnia magna was observed up to the limit of the water solubility of the tested substances.
All four tests were conducted according to EU-Method C.2, which is equivalent to OECD guideline 202. Two of the tests (CAS 67701-30-8 and CAS 65381-09-1) were conducted with additional consideration of the VCI concept for poorly soluble substances. Thus, two different test solutions were prepared: One solution where the test substance was directly weighed into the test vessel and undissolved substance was not removed and a second solution with separation of undissolved substance through filtration (preparation of a Water Accommodated Fraction (WAF)). No effect was observed up to the limit of the water solubility of the tested substances under conditions tested. Furthermore less than 30% of the Daphnids were immobilised in the oversaturated solutions with undissolved test substance. The other two tests (CAS 97722-02-6 and CAS 620-67-7) used filtered test solutions and did not observe effects on Daphnia magna either.
No effect up to the limit of the water solubility for all category members Fatty Acid Glycerides is assumed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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