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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The acute inhalation toxicity study of Landry (1994) was cited in the GLP 28 day repeated dose toxicity study (see section 7.5.2). This acute inhalation toxicity study was as a pre-test for the 28 day repeated dose toxicity study and was conducted in the same laboratory Toxicology Research Laboratory) and with the same study authors as the 28 day repeated dose toxicity study. Therefore, the results are considered reliable even though the study is not reported in detail.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1994
Report date:
1994
Reference Type:
study report
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Aluminium nitride
EC Number:
246-140-8
EC Name:
Aluminium nitride
Cas Number:
24304-00-5
Molecular formula:
AlN
IUPAC Name:
alumanylidyneamine
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Aluminum nitride

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
not specified
Details on test animals or test system and environmental conditions:
no further information available

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
no further information available
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
317 mg/m³
No. of animals per sex per dose:
no data available
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Statistics:
N.A.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 317 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: no remarkable effects were observed
Mortality:
no mortality occured
Clinical signs:
other: no detailed information provided but it was mentioned that no remarkable effects were observed
Body weight:
no detailed information provided but it was mentioned that no remarkable effects were observed
Gross pathology:
no detailed information provided but it was mentioned that no remarkable effects were observed

Any other information on results incl. tables

Aerodynamic Diameter: the mass median aerodynamic diameter was 1.7 µm, with 84% of the particles less than 3.0 µm

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In conclusion, in an acute inhalation toxicity study rats were exposed to 317 mg/m³ for four hours to aluminum nitride. No remarkable adverse effects were noted. Thus, based on the results presented the LC0 can be considered to be greater than 317 mg/m³.
Executive summary:

In an acute inhalation toxicity study rats were exposed to 317 mg/m³ of aluminium nitride for four hours. After treatment the animals were observed for two weeks. The mass median aerodynamic diameter was 1.7 µm, with 84% of the mass in particles less than 3.0 µm. No mortality occurred and no remarkable adverse effects were noted. Thus, based on the results presented the LC0 can be considered to be greater than 317 mg/m³.