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Diss Factsheets
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EC number: 246-140-8 | CAS number: 24304-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The acute inhalation toxicity study of Landry (1994) was cited in the GLP 28 day repeated dose toxicity study (see section 7.5.2). This acute inhalation toxicity study was as a pre-test for the 28 day repeated dose toxicity study and was conducted in the same laboratory Toxicology Research Laboratory) and with the same study authors as the 28 day repeated dose toxicity study. Therefore, the results are considered reliable even though the study is not reported in detail.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium nitride
- EC Number:
- 246-140-8
- EC Name:
- Aluminium nitride
- Cas Number:
- 24304-00-5
- Molecular formula:
- AlN
- IUPAC Name:
- alumanylidyneamine
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Aluminum nitride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no further information available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- no further information available
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 317 mg/m³
- No. of animals per sex per dose:
- no data available
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Statistics:
- N.A.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 317 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: no remarkable effects were observed
- Mortality:
- no mortality occured
- Clinical signs:
- other: no detailed information provided but it was mentioned that no remarkable effects were observed
- Body weight:
- no detailed information provided but it was mentioned that no remarkable effects were observed
- Gross pathology:
- no detailed information provided but it was mentioned that no remarkable effects were observed
Any other information on results incl. tables
Aerodynamic Diameter: the mass median aerodynamic diameter was 1.7 µm, with 84% of the particles less than 3.0 µm
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, in an acute inhalation toxicity study rats were exposed to 317 mg/m³ for four hours to aluminum nitride. No remarkable adverse effects were noted. Thus, based on the results presented the LC0 can be considered to be greater than 317 mg/m³.
- Executive summary:
In an acute inhalation toxicity study rats were exposed to 317 mg/m³ of aluminium nitride for four hours. After treatment the animals were observed for two weeks. The mass median aerodynamic diameter was 1.7 µm, with 84% of the mass in particles less than 3.0 µm. No mortality occurred and no remarkable adverse effects were noted. Thus, based on the results presented the LC0 can be considered to be greater than 317 mg/m³.
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