Registration Dossier
Registration Dossier
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EC number: 246-140-8 | CAS number: 24304-00-5
Endpoint summary
Administrative data
Description of key information
Contact sensitivity to aluminium is very rare. Several review articles report a low incidence of hypersensitization of aluminium compounds even after subcutaneous and intramuscular injections. The risk of hypersensitization after dermal application of a poorly soluble compound like aluminium nitride is considered to be lower compared to subcutaneous injection. Therefore, conducting a vertebrate test with aluminium nitride is considered to be scientifically unjustified and would not respect animal welfare considerations.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Contact sensitivity to aluminium is very rare. Several review articles report a low incidence of hypersensitization of aluminium compounds even after subcutaneous and intramuscular injections. The risk of hypersensitization after dermal application of a poorly soluble compound like aluminium nitride is considered to be lower compared to subcutaneous injection. Therefore, conducting a vertebrate test with aluminium nitride is considered to be scientifically unjustified and would not respect animal welfare considerations.
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