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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: read-across from in vivo experimental test with an analogue
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue Calcium Acetate which shares the same functional group with Zinc Acetate, also has comparable values for the relevant molecular properties for the skin irritation endpoint.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
Read-across approach from Letter of Access experimental data (test method similar to OECD 404) on the analogue Calcium Acetate.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Calcium di(acetate)
EC Number:
200-540-9
EC Name:
Calcium di(acetate)
Cas Number:
62-54-4
IUPAC Name:
calcium diacetate
Details on test material:
- Name of test material (as cited in study report): Calciumacetat
- Molecular formula (if other than submission substance): C2H4O2.1/2Ca
- Molecular weight (if other than submission substance): 158.166
- Smiles notation (if other than submission substance): [Ca+2].[O-]C(C)=O.[O-]C(C)=O
- InChl (if other than submission substance): InChI=1/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #1
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #2
Time point:
other: 24 h
Score:
1
Max. score:
1
Reversibility:
fully reversible within: 48 h
Irritation parameter:
other: redness
Basis:
animal #3
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #1
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #2
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #3
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #1
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #2
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #3
Time point:
other: 9 days
Score:
0
Max. score:
0
Other effects:
Based on the experimental results obtained with the analogue Calcium Acetate, which is considered to be not irritating for Vienna White rabbits skin, and applying the read-across approach, the substance Zinc Acetate is also considered as not irritating under test conditions.

The analogue Calcium Acetate, which shares the same functional group with Zinc Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -1.38 for Calcium Acetate and -1.28 for Zinc Acetate,
- a similar water solubility which is 1.0 g/mL at 25 ºC for Calcium Acetate and 434.78 g/L at 25 ºC for Zinc Acetate, and
- molecular weights which are 158.166 for Calcium Acetate and 183.497 for Zinc Acetate.

Any other information on results incl. tables

The substance Zinc Acetate is considered as not irritating under test conditions.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance Zinc Acetate is considered as not irritating under test conditions.
Executive summary:

Based on the experimental results (reported under the endpoint record 07.03.01_05 CaAc) with the analogue Calcium Acetate, which is considered to be not irritating for Vienna White rabbits skin, and applying the read-across approach, the substance Zinc Acetate is also considered as not irritating under test conditions.