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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

4-Ethylmorpholine is considered as corrosive to the rabbit skin and causing serious eye damage category 1.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation/corrosion:

In a primary skin irritation test according to OECD guideline 404, NEM is administered (0.5mL, occlusive) to the clipped intact dorsal skin during 1min, 5min, 15min or 20 hrs in rabbits. Moderate to severe skin irritation was noted at 24 hours post treatment even after short contact periods of 1 to 15 minutes. The lesions aggravated and developed into full thickness necrosis within 8 days post treatment. NEM is considered corrosive to the skin.

Eye irritation:

In an eye irritation study, NEM is applied (0.05 ml) on eyes of rabbits. The undiluted test substance was administered into the conjunctival sac of the rabbit's eye. Eye reactions were examined at 1 and at 24 hours, and at 8 days post treatment. Severe and persistent eye lesions were noted though the dose volume was only 50% of that required by the OECD guideline 405. Corrosivity to the eyes must be taken into consideration.


Justification for selection of skin irritation / corrosion endpoint:
Reliable in vivo skin irritation study

Justification for selection of eye irritation endpoint:
Reliable in vivo eye irritation study

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Based on the available data and according to the criteria of the CLP Regulation (EC) 1272/2008, NEM should be classified as skin corrosive (category 1) and as serious eye damage (category 1).