Registration Dossier
Registration Dossier
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EC number: 291-759-9 | CAS number: 90480-27-6
Endpoint summary
Administrative data
Description of key information
The test material is not an irritant to either the skin or eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin
In a key study similar to US EPA OPP 81 -5 the test chemical was subjected to skin irritation testing. 0.5 g of the substance was applied to abraded and intact skin of 6 New Zealand White rabbits
No effects were noted at 24 hours on removal of the patches or at 72 hours after application of the test material.
The test material is not an irritant to the skin of rabbits. The test material is not classified in accordance with Regulation (EC) No. 1272/2008.
Eye
In a key study similar to US EPA OPP 81 -4, 0 .1 g of the ground test chemical was placed into the conjunctival sac of one eye of each of 6 New Zealand White rabbits. The untreated eye acted as a control. The eyes were not washed after instillation. Treated eyes were examined at 1, 2, 3, 4 and 7 days after instillation.
Slight conjunctival effects (redness and chemosis) were noted in all 6 animals. Effects were reversible by the 4 -day observation except for redness in one animal which persisted to the 7-day observation. Effects which had reversed at the 4 -day observation recoccurred at the 7 -day observation (2/5 animals (redness) and 3/5 animals (chemosis)). This was considered to be due to the presence of the test material throughout the full 7 -day period in comparison to the current OECD guideline which requires washing of the eye at the 1 hour exposure observation if the material has not been removed by physiological mechanisms.
The test material is not an irritant to the eye of rabbits. The test material is not classified in accordance with Regulation (EC) No. 1272/2008.
Justification for classification or non-classification
The substance is not classified in accordance with EC regulation No 1272/2008 for skin or eye irritation.
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