Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The complete read across justification is detailed in section 13. Test substance is an isomer of the substance under registration; structural difference is not expected to significantly impact the irritation potential. Source study has reliability 2: only limited information available from a migrated NONS file, as per Article 25(3) request.

Data source

Reference
Reference Type:
other: information from migrated NONS file, as per Article 25(3) request, permission to refer granted by ECHA
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Similar Substance 01
IUPAC Name:
Similar Substance 01
Test material form:
solid

Results and discussion

In vivo

Results
Irritation parameter:
erythema score
Basis:
animal: all
Score:
ca. 0
Reversibility:
other: no skin irritation observed
Remarks on result:
no indication of irritation

Any other information on results incl. tables

Blue discolouration of skin noted but not sufficient to occlude the assessment of erythema. No signs of irritation were observed.

Applicant's summary and conclusion

Interpretation of results:
other: not classified according to the CLP Regulation (EC 1272/2008)
Conclusions:
Not irritant.
Executive summary:

Method

Test conducted according to OECD guideline 404. No details on method are available. Information from migrated NONS file, as per Article 25(3) request with permission to refer granted by ECHA.

Results

Blue discolouration of skin noted but not sufficient to occlude the assessment of erythema.No signs of irritation were observed. 

Not irritant.