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EC number: 232-190-8 | CAS number: 7789-79-9
Clinical signs and mortality
Group: G1; Concentration: 3.30 mg/l
Hours indicate time after initiation of the exposure.
N - No abnormal clinical signs; 1 – Nasal discharge, 2 – Abdominal breathing; 8 – Tremors; 5 – Hypoactivity; 27 – Ruffled appearance
Individual animal body weight (g)
Particle size distribution data
Sample No: 1Measured Time: 2 hours
Sample No.: 2Measured Time: 4 hours
The test substance was tested for acute inhalation toxicity to rats in compliance with the OECD Guidelines for Testing of Chemicals, Section 4, No. 403 - "Acute Inhalation Toxicity", adopted 07 September, 2009. The study was conducted as a ‘Limit Test’ in which a group of five male and five female rats were subjected to a single exposure of the test article, for a period of 4 hours at the maximum attainable concentration of 3.30 mg/l. Exposed animals were observed for mortality and signs of toxicity periodically after completion of exposure and thereafter for a period of 14 days, and their body weights were recorded weekly. Necropsy was performed on all rats at termination of the study.
None of the exposed rats died during the 4 hours of exposure to the test substance and no deaths occurred during the 14 day observation post-exposure period. Reversible signs of toxicity, such as nasal discharge, abdominal breathing, tremors, hypoactivity and ruffled appearance were observed; nevertheless, all signs were recovered within 5 days after exposure. The substance did not adversely affect the body weight gain in the treated male and female rats during the 14 day observation period. Necropsy findings did not indicate any remarkable and treatment related gross pathological changes.
LC50 (4h) > 3.30 mg/l
According to the CLP Regulation, the higher threshold limit (based on the LD50) to classify a substance (dust/mist) for acute inhalation toxicity is 5.0 mg/l (category 4: 1.0 < ATE ≤ 5.0 mg/l). In the current test, an LD50 was non identified and the highest dose tested (3.30 mg/l) is lower than the limit outlined in the CLP Regulation for classification. Considering the fact that no mortality occurred, a classification category can not be assigned. Thus, a classification according to the CLP Regulation (EC 1272/2008) is not applicable.
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