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Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
/-/-1α-Ethyl-1,2,3,4,6,7,12,12b α-octahydro-indolo[2,3-a]-quinolizine-1β-yl-ethyl-pyruvate oxime
EC Number:
617-734-8
Cas Number:
85647-38-7
Molecular formula:
C22H29N3O3
IUPAC Name:
/-/-1α-Ethyl-1,2,3,4,6,7,12,12b α-octahydro-indolo[2,3-a]-quinolizine-1β-yl-ethyl-pyruvate oxime

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.22 mg/L
Nominal / measured:
estimated
Remarks on result:
other: QSAR Toolbox Database: Aquatic OASIS
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.59 mg/L
Nominal / measured:
estimated
Remarks on result:
other: T.E.S.T. (Consensus Method)

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: QSAR Toolbox, T.E.S.T., the predicted values indicated that hydroxy-imino-ethyl-ester is hazardous to the fishes. The result meets the requirement of Aquatic Acute Category 1.