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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
/-/-1α-Ethyl-1,2,3,4,6,7,12,12b α-octahydro-indolo[2,3-a]-quinolizine-1β-yl-ethyl-pyruvate oxime
EC Number:
617-734-8
Cas Number:
85647-38-7
Molecular formula:
C22H29N3O3
IUPAC Name:
/-/-1α-Ethyl-1,2,3,4,6,7,12,12b α-octahydro-indolo[2,3-a]-quinolizine-1β-yl-ethyl-pyruvate oxime

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not determined
Species / strain:
E. coli WP2 uvr A
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not determined
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):negativeAccording to (Q)SAR modell: QSAR Toolbox, the predicted values indicated that hydroxy-imino-ethyl-ester is not mutagen.