Registration Dossier
Registration Dossier
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EC number: 251-347-1 | CAS number: 33021-02-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Internal BASF-method was used, which was in large part equivalent to method described in OECD guideline 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-(1,1-dimethylethoxy)-2-methylpropane
- EC Number:
- 251-347-1
- EC Name:
- 1-(1,1-dimethylethoxy)-2-methylpropane
- Cas Number:
- 33021-02-2
- Molecular formula:
- C8H18O
- IUPAC Name:
- 1-(tert-butoxy)-2-methylpropane
- Details on test material:
- - Name of test material (as cited in study report): IBTB.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Weight at study initiation: mean 190 g (males), 180 g (females)
- Diet (e.g. ad libitum): HERILAN-MRH Haltung, Heinrich Eggersmann KG
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: emulsions in 0.5% aqueous CMC with 2-3 drops of Cremophor EL
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50%
- Amount of vehicle (if gavage): 20, 13.62 ml/kg bw
MAXIMUM DOSE VOLUME APPLIED: 3.8 ml - Doses:
- 10000, 6810 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily obervations
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- No mortalities occured.
- Clinical signs:
- other: excitement, spastic gait
- Gross pathology:
- no abnormalities
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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