10-Undecenoic acid, monoester with 1,2,3-propanetriol

Short-term toxicity to aquatic invertebrates

Description of key information

No toxic effects on aquatic invertebrates up to the limit of water solubility. 

Additional information

Data on the acute toxicity of Glyceryl undecylenate (CAS 123759-97-7) to aquatic invertebrates is not available. The assessment was therefore based on a study conducted with the structurally similar substances Glycerides, C8-10 mono- and di- (CAS 85536-07-8) and Glycerides, C14-18 and C16-18-unsatd. mono-, di- and tri- (CAS 91052-28-7) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.

One study evaluating the acute toxicity of Glycerides, C8-C10, mono- and di- (CAS 85536-07-8) to aquatic invertebrates is available (Hafner, 2013). This test was performed according to OECD 202, under GLP conditions. Daphnia magna was exposed to the test substance for a period of 48 hours at nominal loading rates ranging from 5.8 mg/L to 300 mg/L (WAF, according to the results of a non-GLP range-finding test). The test was performed under static water conditions. Analytical measurement of the highest (300 mg/L), two middle (62 and 28.2 mg/L) and the lowest (5.8 mg/L) loading rates was performed via TOC and DOC analysis. After the exposure period, 100% immobilization was reported at the 300 mg/L loading rate, whereas no immobilization was observed in any other treatment group. The resulting EL50 (48 h) was determined to be 218.2 mg/L (based on nominal loading rate) and 102.6 mg/L (based on measured test concentration).

Nevertheless, the observed immobilization seems to be caused by direct physical interference of test substance particles with the daphnids, rather than due to toxicity. The measured concentration at which effects were reported (102.6 mg/L) is well above the water solubility of the source substance (WS 46 mg/L). For this test, Water Accommodated Fractions (WAFs) were prepared by adding the test material into a defined volume of test medium, stirring for a period of 48 hours, followed by a sedimentation period of 1 hour. After the sedimentation period, the WAFs with the highest loading rates appeared to be slightly turbid. The test solutions were prepared without a filtration step.

Although the effect values of the study are to be taken with caution, due to probable physical effects, it can be concluded that no immobilisation occurred up to a concentration of 136.4 mg/L, which is above the water solubility limit of the substance. Therefore, no toxicity of Glycerides, C8-C10, mono- and di- (CAS 85536-07-8) to aquatic invertebrates up to the limit of the water solubility is expected.

The acute toxicity of Glycerides, C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS 91052-28-7) to aquatic invertebrates was investigated in a second read across study (Salinas, 2013). This test was conducted according to OECD 202, under GLP conditions. Daphnia magna was exposed to the substance at a single loading rate of 100 mg/L (limit test) for 48 hours within a static water regime. At the end of the exposure period, no immobilization was observed. Therefore, the EL50 (48 h) was determined to be > 100 mg/L (nominal, loading rate).

Based on the results for the read-across substances, Glyceryl undecylenate (CAS 123759-97-7) is considered not toxic to aquatic invertebrates within the limit of water solubility.