Registration Dossier
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EC number: 918-906-8 | CAS number: 65684-27-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Data on the chronic toxicity of Glyceryl undecylenate (CAS 123759-97-7) to aquatic invertebrates are not available. The substance is readily biodegradable and poorly soluble (8.5 - 182.5 µg/L at 20 °C, pH=6.3). Due to these characteristics, extensive elimination of the substance in conventional STPs can be expected. Therefore, only low concentrations, if any, are likely to be released into the water phase. Exposure of aquatic organisms is thus expected to be low. Furthermore, read across data on short-term toxicity available for all three trophic levels (fish, daphnia and algae) indicate a low potential for aquatic toxicity. In an article by Prajapati et al. (2012) (see IUCLID section 6.1.4), the phase behaviour of lipid/surfactant/water phases was investigated, where medium-chain (C8-10) mono-, di- and triglycerides represent the lipid. Phase boundaries between lipids (monoglycerides, diglycerides, triglycerides), surfactant (PEG-35 castor oil) and water were established by visual inspection after an equilibration period, and the results expressed in phase diagrams. Viscosity and particle size distribution were measured. The mixtures with monoglyceride displayed two predominant phases: microemulsion and emulsion phases, whereas di- and triglycerides showed additionally a gel phase. Mixtures of monoglycerides and diglycerides, and of monoglycerides and triglycerides seemed to promote an increase of the microemulsion phase (in the 4 phases equilibrium). Particle size in these mixtures was found to be much smaller than in the monoglyceride sample alone. Microemulsions are solutions with an average particle size < 0.2 µm. This particle size would not be intercepted by a standard filter used in an aquatic toxicity test (generally, pore size of 0.45 µm). Due to their small size, based on visual inspection, clear or translucent solutions might be observed even when these microemulsions are present.
Further evidence is for a lack of chronic toxicity is given by a long-term toxicity study available for the source substance Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS91052-28-7). This test was conducted according to OECD 211, under GLP conditions (Salinas, 2013). Daphnia magna was exposed to the substance at a single loading rate of 10 mg/L (limit test) for 21 days within a semi-static water regime. At the end of the exposure period, no effects on survival, reproduction or any other adverse effects were reported. Therefore the NOELR (21 d) was determined to be ≥ 10 mg/L (nominal, loading rate).
Based on the results for the read-across substances, Glyceryl undecylenate (CAS 123759-97-7) is considered not chronically toxic to aquatic invertebrates within the limit of water solubility.
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