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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Principles of method if other than guideline:
QSAR TOOLBOX - application of chemical category approach for predicting
GLP compliance:
no
Test type:
other: QSAR and read-across

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
EC Number:
292-054-9
EC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Cas Number:
90530-16-8
IUPAC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
ca. 1.85 mg/L air
Based on:
other: read-across category approach
Remarks on result:
other: read-across category approach

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information H332 Criteria used for interpretation of results: EU
Conclusions:
• Experimental LC50 inhalation data is found for constituent MXDA. It is classified in hazard Category 4.
• Read-across analysis was used for acute inhalation toxicity assessment of constituents A-E. Data category approach was applied for collecting analogues. The performed read-across predictions were focused on the main chemical functionalities present in the target chemicals. Based on the worst read-across prediction all constituents are categorized as Category 4 according to the physical state (CLP/GHS classification).
• Based on the worst-case scenario read-across prediction and applied additive formulate the acute inhalation toxicity of the UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is evaluated as 1.85 mg/L air. According to the obtained value, the UVCB is categorized as a Category 4.
Executive summary:

·        Based on the worst-case scenario read-across prediction and applied additive formulate the acute inhalation toxicity of the UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis evaluated as1.85 mg/L air. According to the obtained value, the UVCB is categorized as a Category 4 (H332).