2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Principles of method if other than guideline:

QSAR TOOLBOX - application of chemical category approach for predicting

GLP compliance:

no

Test type:

other: QSAR and read-across

Test material

Test material information

Constituent 1

Reference substance name:

2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

EC Number:

292-054-9

EC Name:

2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Cas Number:

90530-16-8

IUPAC Name:

2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

ca. 1.85 mg/L air

Based on:

other: read-across category approach

Remarks on result:

other: read-across category approach

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information H332 Criteria used for interpretation of results: EU

Conclusions:

• Experimental LC50 inhalation data is found for constituent MXDA. It is classified in hazard Category 4.
• Read-across analysis was used for acute inhalation toxicity assessment of constituents A-E. Data category approach was applied for collecting analogues. The performed read-across predictions were focused on the main chemical functionalities present in the target chemicals. Based on the worst read-across prediction all constituents are categorized as Category 4 according to the physical state (CLP/GHS classification).
• Based on the worst-case scenario read-across prediction and applied additive formulate the acute inhalation toxicity of the UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is evaluated as 1.85 mg/L air. According to the obtained value, the UVCB is categorized as a Category 4.

Executive summary:

·        Based on the worst-case scenario read-across prediction and applied additive formulate the acute inhalation toxicity of the UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis evaluated as1.85 mg/L air. According to the obtained value, the UVCB is categorized as a Category 4 (H332).