Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference Type:
study report
Report date:

Materials and methods

Principles of method if other than guideline:
QSAR TOOLBOX - application of chemical category approach for predicting acute dermal toxicity
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
EC Number:
EC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Cas Number:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Results and discussion

Effect levels
not specified
Dose descriptor:
Effect level:
ca. 1 492.53 mg/kg bw
Based on:
other: read-across category approach
Remarks on result:
other: read-across category approach

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Migrated information H312 Criteria used for interpretation of results: EU
• Experimental LD50 dermal data is found for constituent MXDA. It is classified in the GHS acute toxicity hazard Category 5.
• Toolbox read-across analysis was used for acute dermal toxicity assessment of 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents A, B, C, D and E. The performed read-across predictions were focused on the main chemical functionalities present in the target chemicals. Based on the worst case-scenario constituents A, B, and D are categorized in the Category 4 and constituents C and E are categorized as Category 5 according to the GHS classification.
• However, analysis of the structural analogues found in the literature classified constituents A to E in GHS Category 4.
• Based on the worst-case scenario read-across prediction and the applied additive formula for the acute dermal toxicity of UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is evaluated as 1492. 53 mg/kg. This value falls in GHS/CLP Category 4.
Executive summary:

2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis evaluated as LD50: 1492. 53 mg/kg. CLP: Acut tox dermal category 4 H312