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EC number: 292-054-9 | CAS number: 90530-16-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: QSAR, read-across
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
- Principles of method if other than guideline:
- • TIMES modeling approach (Eye irritation/corrosion)
• Toolbox 3.3 read-across analysis - GLP compliance:
- no
Test material
- Reference substance name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- EC Number:
- 292-054-9
- EC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- Cas Number:
- 90530-16-8
- IUPAC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: QSAR, read-across
- Basis:
- other: QSAR, read-across
- Remarks on result:
- other: QSAR, read-across
Any other information on results incl. tables
Read-across and QSAR prediction:
· 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:
- ConstituentsMXDA, A and C:Corrosive to eye;
- Constituents B and D:Irritating to eye;
- Constituent E:Non-irritating/corrosive to eye.
· The predictions results are considered reliable:
1) they belong to the TIMES model's and Read-across prediction applicability domains
2) they are supported by expert judgment.
· The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine isclassified inhazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.
Applicant's summary and conclusion
- Interpretation of results:
- Category I
- Remarks:
- Migrated information H318 Criteria used for interpretation of results: EU
- Conclusions:
- The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1) based on the predictions of constituents A and C.
- Executive summary:
· 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:
- ConstituentsMXDA, A and C:Corrosive to eye;
- Constituents B and D:Irritating to eye;
- Constituent E:Non-irritating/corrosive to eye.
· The predictions results are considered reliable:
1) they belong to the TIMES model's and Read-across prediction applicability domains
2) they are supported by expert judgment.
· The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.
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