Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Toxicity to reproduction: other studies

Additional information

·        TIMES Androgen and Estrogen Binding Affinityv.03modelsare used;

·        The modelsarefocused on the direct interactions of chemicals with the androgenand estrogenreceptors(ARand ER) - that is, ARand ERbinding mediated endocrine disruptions. These interactionsareconsidered as primary eventsthat trigger the ultimate biological responses;

2-Propenenitrile, reaction products with 1,3-benzenedimethanamineincluding constituents MXDA, A, B, C and D is predicted asnot capableof eliciting interaction with androgen or estrogen receptors

Justification for classification or non-classification

Not classified as toxicity to reproduction.

Additional information